^99Tc^m—MIBI肿瘤阳性显像在甲状腺癌诊断中的价值  

The diagnostic value of positive ^99Tc^m-MIBI tumor imaging for thyroid cancer

作　　者：于鹏[1] 宫凤玲[2] 李文青[3] 梁永平[1] 尚瑞兴[1] 李琳梅[1] 孟强[1] 

机构地区：[1]河北联合大学附属医院核医学科,唐山063000 [2]河北联合大学附属医院CT室,唐山063000 [3]唐山市中医院

出　　处：《中国综合临床》2011年第8期841-843,共3页Clinical Medicine of China

摘　　要：目的探讨^99Tc^m-MIBI肿瘤阳性显像在诊断甲状腺癌中的应用价值。方法临床怀疑为甲状腺癌患者54例，分别用SPECT进行^99Tc^mO4-甲状腺静态显像和^99Tc^m-MIBI肿瘤阳性显像，将显像结果与手术病理结果进行对照。结果54例患者中，病理结果显示共有甲状腺结节54个，均为单发结节，其中恶性甲状腺结节25个；^99Tc^m-O4-甲状腺静态显像共发现甲状腺结节52个，其中热结节2个，温结节4个，凉结节10个，冷结节36个；2例患者显像结果为阴性。25个恶性甲状腺结节中，发现16个有明显的^99Tc^m-MIBI摄取，均为冷结节；29个良性甲状腺结节中，发现15个有明显的^99Tc^m-MIBI摄取，其中温结节1个，凉结节2个，冷结节12个。^99Tc^mO4-和^99Tc^m-MIBI联合核素显像诊断多发性甲状腺结节伴甲状腺癌的灵敏度为64．00％（16／25），特异度为48．28％（14／29）。甲状腺良、恶性结节的^99Tc^m-MIBI肿瘤显像阳性率差异无统计学意义（X^2=0．83，P〉0．05）。结论^99Tc^m-MIBI肿瘤阳性显像对甲状腺癌的诊断不具有特异性，其临床应用价值有限。Objective To evaluate the value of positive ^99Tc^m-MIBI tumor imaging for thyroid cancer diagnosis. Methods Fifty four suspected thyroid cancer patients underwent ^99Tc^m-O4- and ^99Tc^m-MIBI combined imaging procedure. The imaging data were confirmed by pathological findings. Results All the 54 cases had single throid nodules, and 25 of which were pathologically malignant. Fifty two cases of nodules were detected by the ^99Tc^mO4- thyroid static imaging, including 2 hot nodules,4 warm nodules, 10 cool nodules and 36 cold nodules ;2 cases were negative by the imaging. Of the 25 malignant thyroid nodules, 16 nodules were visible by ^99Tc^m-MIBI uptake and were cold nodules;29 exhibited benign thyroid nodules,of which 15 could be seen by 99Tcm-MIBI uptake,including 1 warm nodules ,2 cool nodules and 12 cold nodules. The sensitivity, specificity of the combined imaging of ^99Tc^m-O4- and ^99Tc^m-MIBI were 64. 00% （16/25） and 48.28% （14/29）. No significant difference was found for the positivity between benign nodules and malignancy nodules by ^99Tc^m-MIBI tumor imaging （ X^2 = 0. 83, P 〉 0. 05 ）. Conclusion ^99Tc^m-MIBI tumor imaging is not specific for the diagnosis of thyroid malignancy.

关 键 词：甲状腺癌 放射性核素 ^99TC^M 

分 类 号：R736.1[医药卫生—肿瘤]