丹红注射液治疗复发脑梗死168例临床效果观察  

Clinical observation of Danhong injection in treatment of 168 cases of recurrently ischemic cerebral stroke

作　　者：马飞月[1] 宋永健[1] 何文绮[1] 周荣英[1] 顾寒英[1] 

机构地区：[1]上海交通大学医学院附属瑞金医院卢湾分院神经内科,200025

出　　处：《蚌埠医学院学报》2011年第8期825-827,共3页Journal of Bengbu Medical College

摘　　要：目的:观察丹红注射液治疗复发脑梗死的临床疗效和安全性。方法:将既往有脑梗死病史的168例住院患者随机分为对照组80例,给予复方丹参注射液静脉滴注;治疗组88例,给予丹红注射液静脉滴注;其余治疗相同。观察2组的临床疗效及治疗前后血浆D-二聚体、纤维蛋白原等血液流变学指标变化水平以及治疗组治疗前后脑微出血影像学变化。结果:治疗组总有效率97.73%,明显高于对照组的91.25%(P<0.01)。治疗组治疗后血浆D-二聚体和纤维蛋白原均降低(P<0.01)。丹红注射液治疗前后患者脑微出血影像学无明显变化。结论:丹红注射液治疗复发脑梗死安全、有效,可在临床进一步推广。Objective：To explore the clinical curative effect of Danhong injection in treatment of recurrently ischemic cerebral stroke.Methods：One hundred and sixty-eight cases of recurrently ischemic cerebral stroke were randomly divided into control group（80 cases） and treatment group（88 cases）.The patients in control group were treated by danshen injection,and patients in treatment group were treated by danhong injection.The clinical curative effect including a score of nerve function as well as changes of hemorheology（D-dimer,fibrinogen）and micro-bleeds were observed between the two groups.Results：The parameters of hemorheology and trauma of nerve function were obviously improved（P〈0.01）.The total effect rate and improvement of hemorheology in treatment group had a significant difference compared with those in control group（P〈0.01）.There was no significant difference demonstrated before and after danhong injection treatment.Conclusions：Danhong injection can improve the parameters of hemorheology and trauma of nerve function of recurrently ischemic cerebral stroke,and without increasing cerebral bleeding tendency obviously.Danhong injection is proved to be effective and safe in treatment of recurrently ischemic cerebral stroke.

关 键 词：脑梗死 丹红注射液 D-二聚体 纤维蛋白原 脑微出血 

分 类 号：R743.33[医药卫生—神经病学与精神病学]