部分恶性肿瘤患者凝血功能的改变与意义  

The change and significance of coagulation function of some patients with malignant tumors

作　　者：陈兴国[1] 徐海伟[1] 张临泉[2] 

机构地区：[1]江苏省徐州医学院第二附属医院检验科,221006 [2]江苏省徐州医学院第二附属医院肿瘤科,221006

出　　处：《检验医学与临床》2011年第16期1933-1934,共2页Laboratory Medicine and Clinic

摘　　要：目的研究通过对食管癌、肺癌、乳腺癌、胃癌、肠癌等恶性肿瘤患者的常规止凝血功能指标检查,探讨部分恶性肿瘤患者凝血功能改变的意义。方法用贝克曼ACL9000全自动血凝仪,采用凝固法原理对98名健康对照,263例恶性肿瘤(食管癌69例,肺癌59例,乳腺癌44例,胃癌52例,肠癌39例)患者的常规凝血功能指标:凝血酶原时间(PT)、部分活化凝血活酶时间(APTT)、凝血酶时间(TT)、纤维蛋白原(Fib)和D-二聚体进行检查。结果恶性癌患者的D-二聚体、Fib水平和健康对照组相比明显增加(P<0.01),且APTT、PT有不同程度的缩短(P<0.01或P<0.05);而大部分肿瘤患者与健康对照组相比TT水平差异无统计学意义(P>0.05)。结论恶性肿瘤凝血功能增强,抗凝及纤溶活性降低,机体处于高凝状态,有血栓形成倾向,而肺癌患者高凝状态更为明显。Objective To study the coagulative function indexes of patients with malignant tumors,such as esophageal cancer,lung cancer,breast cancer,gastric cancer,colorectal cancer,and explore the change of coagulation function of some patients with malignant tumors.Methods We used Beckmann ACL9000 automatic coagulometer freezing method to determine conventional blood function：prothrombin time（PT）,activated partial thromboplastin time（APTT）,thrombin time（TT）,fibrinogen（Fib） and D-dimer of 98 normal controls,263 cases of malignant tumors（69 cases of esophageal cancer,59 cases of lung cancer,44 cases of breast cancer,52 cases of gastric cancer,39 cases of colorectal cancer）.Results The levels of D-dimer,Fib of patients with malignant cancer were higher than those of the normal control group（P〈0.01）,and APTT,PT were reduced（P〈0.01 or P〈0.05）;But the result of TT level between majority of tumor patient and the normal control group compare was not significantly different（P〈0.05）.Conclusion With the strengthen of the coagulation function of the patients with malignant tumor,the activities of anticoagulation and fibrinolytic decrease,and patients are in hypercoagulable state,there is a tendency to form thrombose,which makes the the hypercoagulable state more obvious.

关 键 词：恶性肿瘤 凝血功能 血栓 高凝状态 

分 类 号：R-05[医药卫生]