促凋亡基因PDCD5在新疆维吾尔族与汉族宫颈癌中的表达及临床意义  

Expressions of apoptosis-associated genes PDCD5 in Uygur and Han in Xinjiang in Cervix cancer and its clinical significance

作　　者：刘晓兰[1] 王新华 黄守芬 丁剑冰[1] 马秀敏[1] 

机构地区：[1]新疆医科大学基础医学院,乌鲁木齐830011 [2]新疆石河子人民医院,新疆石河子832000 [3]新疆兵团农五师医院,新疆博乐833500

出　　处：《农垦医学》2011年第2期152-155,共4页Journal of Nongken Medicine

基　　金：国家自然科学基金项目(30871263;30771057)

摘　　要：目的:探讨新疆维吾尔族与汉族宫颈癌组织中PDCD5的表达及其意义。方法:采用免疫组化法检测42例(18例维吾尔族、24例汉族)宫颈癌患者癌组织、正常组织中PDCD5的表达。结果:42例宫颈癌患者癌组织、正常组织中PDCD5表达阳性率为35.7%(15/42)、92.85%(39/42),差异有统计学意义(P<0.05)。结论:⑴PDCD5的表达在不同民族之间无显著性差异,表明在新疆汉族和维吾尔族宫颈癌的发生、发展中PDCD5的表达具有共同性,无民族间差异;⑵PDCD5在宫颈癌患者癌组织中的表达低于正常组织,如进一步研究可能对宫颈癌的治疗提供理论依据。Objective：To evaluate the expression and clinical signifcance of PDCD5 in Uygur and Han in Xinjiang in Cervix cancer. Methods：Using immunohistochemistry used to detect the expression of PDCD5 in 42 patients with Cervix cancer（Uygur 18 cases,24 cases of the Han）. Results：There were the expressions of PDCD5 in Uygur and Han no significant difference（P〉0.05）. Conclusion：⑴the expressions of PDCD5 is not a significance difference among different nationalities,Show that PDCD5 expression of commonality in Han and Uygur in Xinjiang at the occurrence and development of Cervix cancer,no inter-ethnic differences in genetic background;⑵PDCD5 in patients with Cervix cancer than normal Organize,If further studying may offer the theoretical foundation to the treatment of cancer of the Cervix.

关 键 词：宫颈癌 PDCD5 免疫组化 

分 类 号：Q75[生物学—分子生物学] R737.33[医药卫生—肿瘤]