酶屏障抑制剂LB治疗血管源性脑水肿的实验研究  

A study of using inhibitor of enzyme barrier to treat vasogenic brain edema

作　　者：陆兵勋[1] 宁群[1] 王心宇[1] 陈兴洲[1] 

机构地区：[1]广州第一军医大学南方医院神经内科,510515

出　　处：《临床神经病学杂志》1999年第6期323-325,共3页Journal of Clinical Neurology

基　　金：国家自然科学基金

摘　　要：目的　观察酶屏障抑制剂ＬＢ对血管源性脑水肿（ＶＢＥ）的治疗作用。方法　Ｗｉｓｔａｒ大鼠腹腔注射苯肾上腺素制成ＶＢＥ模型，分别注射ＬＢ和甘露醇，用远红外线水份分析仪分别测量灰、白质水份含量。结果　ＬＢ对脑水肿有显著脱水作用，与甘露醇比较有显著差异（Ｐ＜ ０．０１），尤其对白质的脱水作用更显著（Ｐ＜０．０１）。结论　酶屏障抑制剂ＬＢ对脑水肿，尤其对脑白质水肿有选择性治疗作用。是治疗ＶＢＥ的新方法。Objective To observe the effect of the inhibitor of enzyme barrier on vasogenic brain edema(VBE).Methods Injected phenylephrine into abdominal cavity of Wistar rats to make VBE model , one group was given LB , another group was given the mannitol. Water content of gray and white matter was measured with Moisture Analyzer respectively.Results LB had remarkable dehydration on brain edema,and the dehydration on white matter was more obvious than the mannitol( P <0.01). Conclusion LB (the inhibitor of enzyme barrier) has choice treatment effect on brain edema especially white matter. It's a new method of treating VBE.

关 键 词：血管源性 脑水肿 酶屏障 治疗 

分 类 号：R742.705[医药卫生—神经病学与精神病学]