多发性脑梗死性痴呆相关因素和P_(300)的研究  

Study on the related factors and P_(300) in patients with multi infarct dementia

作　　者：李军[1] 袁成林[1] 陈丽明[2] 曹珍兰[2] 

机构地区：[1]扬州大学医学院附属医院神经内科,225001 [2]扬州大学医学院附属医院,225001

出　　处：《临床神经病学杂志》1999年第6期335-337,共3页Journal of Clinical Neurology

摘　　要：目的　探讨多发性脑梗死性痴呆（ＭＩＤ）的相关因素及Ｐ３００对ＭＩＤ的诊断意义。方法　对３８ 例ＭＩＤ和３２ 例无痴呆脑梗死患者的受教育程度、既往史、梗死部位进行对比分析，并用听觉Ｏｄｄ－ｂａｌｌ序列测试Ｐ３００。结果　ＭＩＤ组受教育程度低、高血压史、糖尿病史、≥２ 次卒中史、皮质梗死、皮质合并皮质下梗死、多发性梗死、双侧梗死者与对照组相比均有显著差异（Ｐ＜ ０．０５～０．０１）。ＭＩＤ组Ｐ３００潜伏期明显延长，波幅显著降低。结论　文化水平低、高血压、糖尿病、反复卒中是ＭＩＤ的危险因素。皮质梗死、皮质合并皮质下梗死、多发性梗死、双侧梗死与ＭＩＤ的发生有关。对ＭＩＤ认知功能损害的判断，Ｐ３００ 是一种客观的、有实用价值的电生理学指标。Objective To explore the related factors in the patients with multi infarct dementia (MID) and the diagnostic significance in P 300 for MID. Methods The educated degree, past history and locations of infarction were analysed,and P 300 was performed by auditory event related potentials in 38 patients with MID,and 32 patients with cerebral infarction of without dementia as controls. Results Cases of low educated degree, history of hypertension,diabetes or recurrent strokes,cortex infarction,cortex combining subcortex infarction,bilateral cerebral infarction and multiple cerebral infarction were more frequently in the MID group compared with the control group ( P <0.05~0.01). Delayed peak latency and reduced amplitude of P 300 were found in the MID group. Conclusions Low educated degree, history of hypertension,diabetes or recurrent strokes might be the risk factors for MID. Cortex infarction,cortex combining subcortex infarction,bilateral cerebral infarction and multiple cerebral infarction might be associated with MID; P 300 was an objective and valuable index in evaluating the cognitive dysfunction in patients with MID.

关 键 词：多发性 脑梗死性痴呆 相关因素 P300 

分 类 号：R749.102[医药卫生—神经病学与精神病学]