肿瘤干细胞与肿瘤转移  

Research progress of the relationship between cancer stem cell and cancer metastasis

作　　者：黄学德[1] 孙芬芬[1] 叶小群[1] 

机构地区：[1]南昌大学第二附属医院呼吸科,南昌330006

出　　处：《生命的化学》2011年第4期502-505,共4页Chemistry of Life

基　　金：江西省教育厅科学技术研究资助项目(GJJ10345)资助

摘　　要：近年来,肿瘤干细胞(cancer stem cell,CSC)学说研究认为CSC与肿瘤发生、发展、转移和复发关系极为密切。研究还发现CSC具有明显的异质性,即CSC可分为增生、耐药、侵袭和转移等行为不同的亚群细胞,其中具有转移生物学特性的CSC亚群细胞称为肿瘤转移干细胞(migrating cancer stem cell,MCSC)。目前认为,上皮-间质转变、趋化因子和靶器官微环境可能在肿瘤转移过程中起着重要作用。针对MCSC及其相关机制的靶向治疗有望能更有效地遏制肿瘤的转移。According to the cancer stem cell(CSC) hypothesis,CSCs are closely related to the production,growth,transfer and recurrence of tumor.CSCs also have obvious heterogeneity i.e CSC can be divided into several subgroups of cells with different profiles of hyperplasia,drug resistance,invasion and metastasis.Among these subgroups,the subgroups of cells with the biological characteristics of metastasis are named migrating cancer stem cells(MCSCs).In addition,different impact factors,including the epithelial-mesenchymal transition(EMT),chemotactic factor and niche of the target organ,may play critical roles in CSC metastasis.The treatment for targeted MCSC and their related mechanisms should be effective in halting the metastasis of cancer.

关 键 词：肿瘤干细胞或转移肿瘤干细胞 转移 

分 类 号：R730.2[医药卫生—肿瘤]