p38丝裂原活化蛋白激酶信号转导通路与角膜新生血管  

Advances on p38 signal transduction pathway and corneal neovascularization

作　　者：张海峰[1] 钟彦彦[1] 陆晓和[1] 

机构地区：[1]南方医科大学珠江医院眼科,中国广东省广州市510282

出　　处：《国际眼科杂志》2011年第9期1564-1566,共3页International Eye Science

基　　金：中国广东省科技计划项目资助(No.2008B080703037)~~

摘　　要：炎症是促进角膜新生血管生长的重要因素。p38丝裂原活化蛋白激酶信号转导通路通过调控IL-1β,IL-6和TNF-α等的表达,从而在炎症反应中发挥重要作用。p38抑制剂不仅抑制炎性介质的表达,而且阻断其功能,因此在抑制炎症反应中具有重大作用。从p38信号转导角度研究角膜新生血管的形成机制,是角膜新生血管机制研究的新方向。Inflammation can promote the growth of corneal neovascularization.p38 mitogen-activated protein kinase signal transduction pathway may play an important role in the progress of inflammation by controlling the expressions of IL-1β,IL-6,TNF-α and so on.p38 inhibitors not only suppress the expressions of inflammatory mediators,but also block their activities.p38 inhibitors greatly curb the progress of inflammations.It is a new strategy to explore the developing mechanism of corneal neovascularization through the pathway of p38 signal transduction.

关 键 词：丝裂原活化蛋白激酶 P38 信号转导 角膜新生血管 

分 类 号：R779.65[医药卫生—眼科]