聚焦超声对外阴上皮内非瘤样病变组织生物学行为的影响  

The Effects of Ultrasound Treatment on Biological Behaviors of Nonneoplastic Epithelial Disorders of Vulva

作　　者：刘毅[1] 熊郁[1] 李成志[1] 陈丽萍[1] 范秀芳[1] 

机构地区：[1]重庆医科大学生物医学工程系,重庆市400016

出　　处：《中国超声医学杂志》2011年第8期749-751,共3页Chinese Journal of Ultrasound in Medicine

基　　金：教育部"长江学者与创新团队发展计划"资助项目(No.IRT0454)

摘　　要：目的探讨聚焦超声对外阴上皮内非瘤样病变组织生物学行为的影响。方法观察聚焦超声治疗前后外阴上皮内非瘤样病变患者临床症状体征变化和疗效评分;HE染色法检测其病理改变,免疫组化法检测其人原始造血细胞抗原(CD34)、髓磷脂碱性蛋白(MBP)表达水平的变化。结果聚焦超声治疗后,瘙痒症状消失,外阴皮肤外观逐渐恢复正常;上皮细胞层数恢复正常且排列整齐,基底层内黑色素细胞增加,真皮内的微血管和神经末梢增多,淋巴细胞浸润明显减少;CD34、MBP表达较治疗前明显增高(P<0.05),各类型之间并无明显差异。结论聚焦超声治疗可促进外阴上皮内非瘤样病变局部微血管、神经系统正常转归。Objective To study the cell metabolism and biological behaviors of nonneoplastic epithelial disorders of vulva after focused ultrasound treatment, Methods The clinical symptom, sign and score were observed; HE stain and immunohistochemistry were performed to detect the pathologic change and the expression of human hematopoietic cell antigen （CD34） and myelin basic protein （MBP） pre-ultrasound treatment and post-treatment, respectively. Results After ultrasound treatment, pruritus was disappeared, the appearance of vulva skin was turn to normal. The layer number of epithelial cells recovery and arrangement regularity, melanocyte in basal layer and microvessel and nerve endings in dermal increased, lymphocytic infiltration decreased; the expression of CD34, MBP were increased obviously in vulva tissues, as compared with those of pre-treatment. There is a significant difference between pre- and post-treatment （P〈0.05）, except categories. Conclusions This study showed that ultrasound treatment could promote local microvasculars and nervous system of the nonneoplastic epithelial disorders of vulva turn to normal and have a better prognosis.

关 键 词：超声治疗 外阴上皮内非瘤样病变 生物学行为 

分 类 号：R737.33[医药卫生—肿瘤] R454.3[医药卫生—临床医学]