角鲨烯对小鼠缺氧耐受力的影响  

Effect of Squalene on Mice's Anoxia Endurance

作　　者：黄宗锈[1,2] 陈冠敏[1,2] 林春芳[1,2] 吴丽琨[3] 

机构地区：[1]福建省疾病预防控制中心毒理科,福建福州350001 [2]福建省实验动物质量检测中心 [3]福建中医药大学

出　　处：《实用预防医学》2011年第8期1540-1541,共2页Practical Preventive Medicine

摘　　要：目的探讨角鲨烯对小鼠缺氧耐受力的影响。方法将小鼠按体重随机分为低、中、高3个剂量组和对照组,连续给药30 d,采用常压耐缺氧法、亚硝酸钠中毒致死法及急性脑缺血性缺氧法分别记录小鼠耐缺氧存活时间、亚硝酸钠中毒存活时间及急性脑缺血后喘气时间。结果在连续给予角鲨烯30 d后,中、高剂量组小鼠在注射亚硝酸钠后,能延长存活时间,与对照组相比差异有统计学意义(P<0.05);在急性脑缺血性缺氧条件下,中、高剂量组小鼠能延长喘气时间,与对照组相比,差异有统计学意义(P<0.05),且对小鼠体重增长无影响。表明角鲨烯对急性脑缺血性和亚硝酸钠中毒缺氧具有保护作用。结论角鲨烯具有提高小鼠缺氧耐受力的作用。Objective To explore the effect of squalene on anoxia endurance in mice.Methods Mice were randomly divided into low-,middle-,and high-dosage groups and control group,and then squalene was orally given in three dosages groups for 30 consecutive days.The survival time in mice exposed to hypoxia under the normal pressure,with sodium nitrite or after acute cerebral ischemia was examined.Results After giving squalene for 30 consecutive days,mice injected with sodium nitrite in middle-and high-dosage groups survived longer than those in control group,and the differences were statistically significant（P0.05）.Mice with acute cerebral ischemia in middle-and high-dosage groups survived longer than those in control group,and the differences were statistically significant（P0.05）.Effect of squalene on mice＇s body-weight growths was not observed.These results indicated that squalene could protect mice from anoxia caused by acute cerebral ischemia and sodium nitrite poisoning.Conclusions Squalene can enhance anoxia endurance function in mice.

关 键 词：角鲨烯 缺氧耐受力 小鼠 

分 类 号：R-332[医药卫生]