表皮生长因子受体和肿瘤微血管生成与胸腺瘤临床病理的相关性  

Clinicopathologic Correlation of Epidermal Growth Factor Receptor and Tumor Angiogenesis in Thymoma

作　　者：孟优[1] 俞士尤[1] 刘标[2] 

机构地区：[1]苏州市立医院东区肿瘤外科,江苏苏州215001 [2]苏州市立医院东区病理科,江苏苏州215001

出　　处：《苏州大学学报（医学版）》2011年第3期462-465,468,共5页Suzhou University Journal of Medical Science

摘　　要：目的探讨表皮生长因子受体(EGFR)表达、微血管密度(MVD)在判断胸腺瘤浸润、复发和转移及其预后分析中的临床意义。方法用免疫组织化学Envision法检测单克隆抗体EGFR、CD34在57例胸腺瘤患者中的表达,并结合53获随访患者的随访资料进行预后分析。结果 68%胸腺瘤呈EGFR过表达,EGFR过表达与组织学类型无关(P>0.05);浸润性胸腺瘤和复发/转移组EGFR过表达率分别高于包膜内胸腺瘤和非复发/转移组,差异均有统计学意义(均P<0.05)。MVD在胸腺瘤不同类型之间总体差异有高度统计学意义(P<0.01);浸润性胸腺瘤和复发/转移组MVD分别高于包膜内胸腺瘤和非复发/转移组,差异均有统计学意义(均P<0.05)。Kaplan-Meier生存曲线显示:EGFR过表达和高MVD患者5生存率和10年生存率均低于对照组,但差异无统计学意义(均P>0.05)。结论胸腺瘤显示EGFR过表达和活跃的肿瘤微血管生成,EGFR过表达和高MVD值有助于判断胸腺瘤的浸润、复发和转移,对评估患者的预后有一定参考价值。Objective To assess the correlation between epidermal growth factor receptor（EGFR）,microvessel density（MVD） and a series of pathological characteristics and the prognostic value of thymoma.Methods The expression of EGFR and CD34 was investigated by immunohistochemistry method from 57 cases of thymoma.Overall survival of 53 patients was estimated using the Kaplan-Meier method.Results The overexpression of EGFR protein was observed in 68% of thymomas.There was no significant difference of EGFR overexpression between the two histological subtypes（P0.05）.EGFR overexpression was higher in the invasive thymomas and thymomas with recurrence and/or metastases than that in the encapsulated thymomas and thymomas without recurrence and/or metastases（P0.05）.A significantly difference of MVD value was found among different types of thymoma（P0.01）.MVD was higher in the invasive thymomas and thymomas with recurrence and/or metastases than that in the encapsulated thymomas and no recurrence and/or metastases（P0.05）.The Kaplan-Meier survival curves showed that thymomas with EGFR overexpression and higher MVD value had a relatively poor survival,but the significant difference was not observed（P0.05）.Conclusion These data provide evidence that EGFR overexpression and higher MVD value can be used to predict invasion,recurrence and metastases of thymomas,and at least in part,to evaluate clinical prognosis.

关 键 词：胸腺瘤 表皮生长因子受体 微血管密度 

分 类 号：R736.3[医药卫生—肿瘤]