醒神液抑制阿尔茨海默病模型大鼠脑神经细胞凋亡的观察  

The Abservation of Xingshen Liquid Restraining the Apoptosis of Brain Neuron of Alzheimer Disease Model Rats

作　　者：匡忠生[1] 谢宇晖[1] 

机构地区：[1]广州中医药大学第一附属医院病理科,广东广州510405

出　　处：《中国医药指南》2011年第23期181-181,190,共2页Guide of China Medicine

基　　金：广东省中医药管理局2004年度立项课题(101071)

摘　　要：目的从抑制脑神经细胞凋亡观察醒神液对阿尔茨海默病(Alzheimer disease,AD)的治疗作用及机理。方法用D-半乳糖和鹅膏蕈氨酸制备大鼠AD模型,并同时用醒神液对其进行治疗,采用TUNEL和图像分析法观察脑皮质和海马神经细胞凋亡的变化。结果醒神液治疗组脑皮质及海马神经元凋亡数及凋亡积分光密度明显降低,治疗效果高剂量组优于低剂量组,呈明显量效关系。结论醒神液能减轻AD模型大鼠神经细胞凋亡,对AD有一定的防治作用。Objective To abserve the curative effect and mechanism of Xingshen Liquid curring AD from the aspect of restraining the apoptosis of neuron.Method To make AD rat model with D-galactose and Ibotenic acid,At the same time cure the AD model rat with Xingshen Liquid,and then observe the changes of apoptosis of the cerebral and hippocampial neuron with TUNEL and image analysis.Results The number and integral optical density significantly reduced of the cerebral and hippocampial neuron after cured with Xingshen Liquid,and the curative effects is related to the concentration of Xingshen Liquid.Conclusion Xingshen Liquid can restrain The apoptois of cerebral neuron in AD model rats,and has curative effect to AD.

关 键 词：中药 阿尔茨海默病 细胞凋亡 

分 类 号：R749.16[医药卫生—神经病学与精神病学]