负载脯氨酸及其衍生物催化的不对称C—C键形成反应研究进展  

Research Progress in Supported Proline and Proline Derivatives as Recyclable Organocatalysts for Asymmetric C—C Bond Formation Reactions

作　　者：刘玉霞[1,2] 杨柳[2] 马志伟[1] 王川川[1] 陶京朝[1] 

机构地区：[1]郑州大学化学系,河南郑州450052 [2]河南工程学院材料与化学工程系,河南郑州450007

出　　处：《催化学报》2011年第8期1295-1311,共17页

基　　金：国家自然科学基金(20372059);河南工程学院博士基金(D09002)~~

摘　　要：近年来脯氨酸及其衍生物催化的不对称有机反应受到了广泛关注,将其负载于载体上使用也引起了人们的极大兴趣.负载方式大致分为3种:共价键负载,离子对结合或物理吸附等作用负载,以及在离子液体中的两相催化剂.本文对近年来出现的负载脯氨酸及其衍生物催化的不对称反应(Aldol反应、Michael加成反应)研究进展进行了综述.In recent years, L-proline and L-proline derivatives were successfully used as organocatalysts in asymmetric reactions. There are three different general approaches for organocatalyst immobilization： covalently supported catalysts, non-covalently supported catalysts, and biphasic catalysts in ionic liquids. This review summarizes some immobilized organocatalysts, highlighting their application, recoverability, and reusability in Aldol and Michael addition reactions.

关 键 词：负载型催化剂 有机催化 L-脯氨酸 碳-碳键形成反应 

分 类 号：O643.32[理学—物理化学]