检索规则说明:AND代表“并且”;OR代表“或者”;NOT代表“不包含”;(注意必须大写,运算符两边需空一格)
检 索 范 例 :范例一: (K=图书馆学 OR K=情报学) AND A=范并思 范例二:J=计算机应用与软件 AND (U=C++ OR U=Basic) NOT M=Visual
作 者:魏小龙[1] 冯睿[1] 赵志青[1] 景在平[1]
机构地区:[1]第二军医大学长海医院血管外科,上海200433
出 处:《中西医结合学报》2011年第8期866-870,共5页Journal of Chinese Integrative Medicine
摘 要:背景:下肢静脉功能不全(chronic venous disorder,CVD)常导致色素沉着等皮肤营养改变,如不能获得有效治疗,可发展至皮肤溃疡坏死等严重并发症。目的:评估脉络舒通颗粒和喜辽妥乳膏治疗下肢CVD色素沉着的临床疗效。设计、场所、对象和干预措施:所有病例均为2010年8月至12月长海医院血管外科的门诊CVD患者。采用随机、对照的研究方法,将108例CVD色素沉着患者分为脉络舒通组(仅给予脉络舒通颗粒)、喜辽妥组(仅给予喜辽妥乳膏)和联合治疗组(同时给予脉络舒通颗粒和喜辽妥乳膏)。疗程为28d。主要结局指标:观察治疗前后CVD色素沉着区域的面积和平均灰度值的改变。结果:脉络舒通组33例,喜辽妥组34例,联合治疗组31例纳入统计分析。经治疗后3组患者皮肤色素沉着面积均减小,平均灰度值均降低(P<0.05)。联合治疗组色素沉着面积减小和平均灰度值降低程度较脉络舒通组和喜辽妥组更为明显(P<0.05),而脉络舒通组和喜辽妥组组间比较差异无统计学意义(P>0.05)。结论:脉络舒通颗粒和喜辽妥软膏对下肢CVD皮肤色素沉着均具有良好的疗效,二者合用则效果更佳。Background:Chronic venous disorder(CVD)of the lower extremities generally induces dermatologic complications in lower extremity skin,such as hyperpigmentation.If not treated effectively,the lesions may develop into severe outcomes,including dermal ulcer or necrosis.Objective:To evaluate the clinical efficacy of Mailuo Shutong Granule,a compound traditional Chinese herbal medicine,and Hirudoid cream(heparinoid),in treatment of patients with dermal hyperpigmentation of skin caused by CVD.Design,setting,participants and interventions:A total of 108 CVD outpatients with pigmentation from Department of Vascular Surgery,Shanghai Changhai Hospital were randomly divided into Mailuo Shutong group,Hirudoid group and combined therapy group,with 36 patients in each group.Patients in the Mailuo Shutong group and the Hirudoid group were treated with Mailuo Shutong Granule or Hirudoid cream,respectively,while those in the combined therapy group were treated with Mailuo Shutong Granule plus Hirudoid cream.They were all treated for 28 d.Main outcome measures:Before and after the 28-day treatment,area and average gray value of pigmentation lesions were measured and evaluated.Results:Thirty-three cases in the Mailuo Shutong group,34 cases in the Hirudoid group and 31 cases in the combined therapy group were included for analysis.After treatment,area of pigmentation decreased and average gray value of pigmentation declined in all the 3 groups(P〈0.05).The reductions of area and average gray value in the combined therapy group were more significant than those in the Mailuo Shutong group and Hirudoid group(P〈0.05).There were no differences in improvement of pigmentation between the Mailuo Shutong group and Hirudoid group(P〉0.05).Conclusion:These data suggest that both Mailuo Shutong Granule and Hirudoid cream can improve CVD-induced hyperpigmentation,and combined treatment of the two drugs results in better clinical efficacy.
正在载入数据...
正在载入数据...
正在载入数据...
正在载入数据...
正在载入数据...
正在载入数据...
正在载入数据...
正在链接到云南高校图书馆文献保障联盟下载...
云南高校图书馆联盟文献共享服务平台 版权所有©
您的IP:18.223.188.252