膳食诱导肥胖小鼠生殖功能变化的试验研究  

STUDY ON THE CHANGE OF REPRODUCTIVE FUNCTION CAUSED BY OBESITY

作　　者：张颖花[1] 翟玲玲[1] 张春东[2] 白英龙[1] 白霞[3] 宿文辉[3] 邓洁[3] 

机构地区：[1]中国医科大学公共卫生学院,沈阳110001 [2]中国医科大学临床医学系七年制 [3]中国医科大学基础医学院

出　　处：《现代预防医学》2011年第16期3179-3181,共3页Modern Preventive Medicine

基　　金：国家自然科学基金资助 (30800920; 30700669)

摘　　要：[目的]探讨肥胖倾向(DIO)、抵抗和对照小鼠高脂饮食后性腺,睾丸精子数量、活动度的变化情况。[方法]小鼠高脂膳食19周,分离睾丸、附睾和精囊腺,并称重,检测精子活动度和精子数量。[结果]实验19周末,DIO组小鼠睾丸和附睾系数显著低于对照组小鼠;DIO小鼠的精子活动度显著低于对照组小鼠。[结论]长期肥胖可能影响小鼠生殖器官的发育,影响小鼠精液品质。[Objective]To study the change of gonad,the number and activity of sperm caused by obesity.[Methods]High-fat diet was given in 19w. Testis,epididymis,and seminal vesicles were isolated and weighed,and the number and activity of sperm were detected.[Results]In 19w,the testis and epididymis of DIO mice were significantly lower than the control mice. Sperm activity of DIO mice was significantly lower than control mice.[Conclusion]Obesity may affect the development of reproductive organs in mice,and affect sperm quality in mice.

关 键 词：肥胖 生殖 膳食诱导 

分 类 号：R151[医药卫生—营养与食品卫生学]