埃索美拉唑联合枸橼酸莫沙必利治疗胃食管反流病的疗效评价  

THE EFFECT EVALUATION OF ESOMEPRAZOLE COMBINED WITH MOSAPRIDE IN TREATMENT WITH GASTROESOPHAGEAL REFLUX DISEASE

作　　者：潘茜[1] 秦扬[1] 

机构地区：[1]海南省中医院西药房,海口570203

出　　处：《现代预防医学》2011年第16期3342-3343,共2页Modern Preventive Medicine

摘　　要：[目的]观察埃索美拉唑联合枸橼酸莫沙必利治疗胃食管反流病的临床疗效。[方法]2007年9月~2010年9月,92例食管反流病患者随机分为两组,对照组46例仅采用奥美拉唑联合多潘立酮治疗,观察组46例采用埃索美拉唑联合枸橼酸莫沙必利治疗,比较观察两组的临床疗效和主要症状变化。[结果]观察组的总有效率明显高于对照组,两组比较差异有统计学意义（P﹤0.05）。两组治疗后烧心、反酸和胸骨后疼痛评分均较治疗前下降,差异有统计学意义（P﹤0.05）。观察组治疗后烧心、反酸和胸骨后疼痛评分均低于同期对照,差异有统计学意义（P﹤0.05）。[结论]埃索美拉唑联合枸橼酸莫沙必利治疗GERD,能够明显提高临床疗效,改善临床症状,是一种良好的联合用药方案。[Objective]To evaluate esomeprazole combined with mosapride in treatment with gastroesophageal reflux disease.[Methods]From September 2007 to September 2010,92 cases of gastroesophageal reflux disease patients were randomly classified into two groups,which observation group with 46 cases was treated with esomeprazole combined with mosapride and control group with 46 cases was treated with omeprazole combined with domperidone. The clinical effect and main symptoms were observed and compared.[Results]The total effective rates in observation group were significantly higher than that in control group（P﹤0.05）. Compared with pre-treatment,the scores of heartburn,acid reflux and chest pain were significantly decreased（P﹤0.05）after treatment in both two groups. Moreover,the scores of heartburn,acid reflux and chest pain in observation group after treatment were significantly lower than those in control group（P﹤0.05）.[Conclusion]Esomeprazole combined with mosapride in treatment of gastroesophageal reflux disease can improve clinical curative effect,improve clinical symptoms,which can be applied in clinic.

关 键 词：埃索美拉唑 枸橼酸莫沙必利 胃食管反流病 

分 类 号：R57[医药卫生—消化系统]