帕利哌酮缓释片对急性期精神分裂症患者社会功能的影响  

Efficacy of paliperidone extended-release tablets on improving social function in acute patients with schizophrenia

作　　者：刘振花[1] 郑云哨[2] 张天亮[2] 安璐璇[1] 

机构地区：[1]山东大学医学院,济南250012 [2]山东省精神卫生中心,济南250014

出　　处：《山东大学学报（医学版）》2011年第8期100-103,共4页Journal of Shandong University:Health Sciences

摘　　要：目的比较帕利哌酮缓释片与常用经典和非经典抗精神病药对急性期精神分裂症患者社会功能的影响。方法将154例患者分为经典抗精神病药治疗组(经典组44例)、非经典抗精神病药治疗组(非经典组57例)及帕利哌酮缓释片治疗组(53例),分别于入组时和治疗后第4、12、24周末采用阳性与阴性症状量表(positive andnegative symptoms scale,PANSS)和个人与社会表现量表(personal and social performance scale,PSP)进行评定。结果治疗后第4周末帕利哌酮组PANSS各因子分及总分均低于非经典组,非经典组低于经典组,差异有统计学意义(P<0.05或P<0.01)。第12和24周末,帕利哌酮组与非经典组阴性症状分及总分低于经典组,差异有统计学意义(P<0.05)。治疗后帕利哌酮组PSP评分高于非经典组,更高于经典组,差异有统计学意义(P<0.01)。结论急性期用药能改善患者的精神症状及社会功能,非经典抗精神病药物,尤其是帕利哌酮缓释片,优于经典抗精神病药物。Objective To compare the effects of paliperidone extended-release （paliperidone ER） tablets with commonly used typical and atypical antipsychotic drugs on social function in acute patients with schizophrenia. Methods A total of 154 patients were divided into three treatment groups： the typical antipsychotics group （ ＂Typical Group＂ ）, the atypical antipsychotics group （＂ Atypical Group＂） and the paliperidone extended-release tablets group （＂ Paliperidone Group＂ ）. All patients were assessed with the Positive and Negative Symptoms scale （ PANSS ）, and the Personal and Social Performance scale （PSP） before and after each treatment regime. Results At the end of the 4th week of treatment, the Paliperidone Group had significantly lower scores for both total and sub-factors on PANSS than the Atypical Group, and the latter had lower scores than the Typical Group （ P 〈 0.01 or P 〈 0.05 ）. At the ends of the 12th and 24th week of treatment,the Atypical Group and the Paliperidone Group both had significantly lower total scores and negative symptom scores than the Typical Group（ P 〈0.05 or P 〈0.01 ）. Assessed with the PSP at the ends of the 4th, 12th and 24th week, the Paliperidone Group scored significantly higher than the Atypical Group （ P 〈 0.01 ）, and even higher than the Typical Group （ P 〈 0.05）. Conclusion Psychotic symptoms and social function can be improved with antipsychotic drugs in the acute phase of schizophrenia patients, and atypical antipsychotics, especially paliperidone ER are superior to typical antipsychotics.

关 键 词：精神分裂症 抗精神病药物 社会功能 急性期 

分 类 号：R749.3[医药卫生—神经病学与精神病学]