精神药物的不良反应(三) 长期住院精神分裂症患者伴发代谢综合征情况  

Investigation of metabolic syndrome in long-term schizophrenic inpatients

作　　者：陈丽[1] 杨贵刚[1] 张兴理[1] 付卫红[1] 

机构地区：[1]北京回龙观医院,100096

出　　处：《临床精神医学杂志》2011年第4期272-273,共2页Journal of Clinical Psychiatry

摘　　要：目的:了解长期住院精神分裂症患者伴发代谢综合征(MS)的情况。方法:抽样调查住院至少2年以上的长期住院精神分裂症患者,测定患者身高、腰围、体质量及代谢指标,依据世界糖尿病联盟(IDF)规定的诊断标准甄别出MS患者;同时调查与之相关的抗精神病药使用情况。结果:MS发生率为43.4%,女性52.0%高于男性34.9%(χ2=7.420,P<0.01);Logistic回归分析发现MS与性别、体质量指数有关;抗精神病药种类与MS发生无显著相关。结论:长期住院接受抗精神病药治疗的精神分裂症患者伴发MS较高。Objective：To investigate the prevalence of the metabolic syndrome in the long term schizophrenic inpatients.Method：Two hundred and forty-nine schizophrenics in hospital for at least 2 years were sampled.After the measurement of height,waist circumference,body weight as well as metabolic index,the patients were judged whether they were accompanied with MS（metabolic syndrome）according to the MS criteria of IDF（International Diabetes Federation） and the related antipsychotic drug uses were investigated.Results：Of the 249 subjects,one hundred and eight（43.4%） met the MS criteria,with higher prevalence of female patients than that of male ones 52.0% vs 34.9%（χ2=7.420,P0.01）.Logistic regression analysis showed that gender and body mass index were related significantly with MS.There were no significant differences among sorts of antipsychotics and occurrence of MS.Conclusion：Schizophrenic inpatients with long term antipsychotic-treatment have higher occurrence of MS.

关 键 词：精神分裂症 抗精神病药 代谢综合征 

分 类 号：R749.3[医药卫生—神经病学与精神病学]