老年性痴呆与钙代谢障碍相关性的可能机制  

Correlation of Alzheimer's disease with calcium metabolism disorders in elderly patients and its possible mechanism

作　　者：宋博毅[1] 张艳梅[1] 

机构地区：[1]河北联合大学附属医院老年病科,河北省唐山市063000

出　　处：《实用老年医学》2011年第4期304-305,共2页Practical Geriatrics

摘　　要：目的探讨老年性痴呆与钙代谢障碍的相关性及其可能机制。方法通过检测157例老年阿尔茨海默病(AD)患者及200例正常老年体检者的血清钙浓度及血浆超氧化物歧化酶(SOD)、丙二醛(MDA)的浓度,探讨钙代谢障碍引起老年AD的可能机制。结果老年AD组与健康对照组相比,血钙及SOD浓度明显降低,MDA水平明显升高,差异有统计学意义。经Pearson相关分析,AD组MDA、SOD浓度与血钙浓度密切相关。结论老年性AD与钙代谢障碍的相关,可能与血钙水平降低引起氧化应激反应有关。Objective To study the correlation of Alzheimer＇s disease（AD） and calcium metabolism disorders and its possible mechanism. Methods The levels of serum calcium and superoxide dismutase （SOD）, malondialdehyde（ MDA ） in 157 AD patients and 200 normal elderly subjects were measured to analyze the possible mechanism of AD caused by calci- um metabolism disorders. Results Compared with control group, the serum levels of calcium and SOD in patients with AD were significantly lower, and the level of MDA was significantly increased. Pearson correlation analysis showed that the levels of MDA and SOD in the patients with AD was closely related with the level of serum calcium. Conclusions The mechanism of AD might be associated with oxidative stress caused by lower blood calcium levels.

关 键 词：老年性痴呆 超氧化物歧化酶 丙二醛 

分 类 号：R749[医药卫生—神经病学与精神病学]