内蒙古东部地区2005～2010年宫颈癌及宫颈上皮内瘤变的机会性筛查研究  

The Investigation of Cervical Cancer and Cervical Precancerous Lesions in Opportunistic Cervical Cancer Screening Among Women From Eastern Area of Inner Mongolia in 2005～2010

作　　者：白鹏来[1] 宋伟奇[2] 梁英 佟力军 张龙[5] 段仙芝[6] 

机构地区：[1]内蒙古民族大学,2008级研究生内蒙古通辽028000 [2]内蒙古民族大学附属医院妇产科,内蒙古通辽028000 [3]兴安盟人民医院病理科,内蒙古乌兰浩特137400 [4]内蒙古林业总医院病理科,内蒙古牙克石022150 [5]赤峰学院附属医院检验科,内蒙古赤峰024000 [6]北京同仁医院妇产科,北京100176

出　　处：《内蒙古医学杂志》2011年第5期519-523,共5页Inner Mongolia Medical Journal

基　　金：内蒙古地区子宫颈癌的预防及癌前病变的干预(20070501)

摘　　要：目的:调查研究内蒙古东部地区就诊患者中宫颈癌及宫颈上皮内瘤变的患病情况,为临床和教学科研提供数据资料。方法:本研究是以医院为基础的横断面筛查研究,以内蒙古东部地区18~69岁来医院或妇幼保健所就诊的妇女为研究对象,采集其宫颈脱落细胞液基标本,异常者进行阴道镜检,必要时取病理活检明确诊断。细胞学诊断采用TBS分级系统,阳性定义为意义不明确的非典型鳞状上皮细胞不除外HSIL(ASC-H)以及更高度病变,以组织病理学为金标准,分析各年龄组患者宫颈癌及宫颈上皮内瘤变的发病规律及蒙古族与汉族妇女宫颈癌及宫颈上皮内瘤变的发病趋势。结果:①细胞学阳性率最高年龄段为25~29岁,SCC的高发年龄段为55~59岁,高度病变的患病率最高年龄段45~49岁,低度病变的患病率最高的年龄段为25~29岁、CIN的高发年龄段为45~49岁和40~44岁,高度CIN(CINⅡ~CINⅢ)的高发年龄45~49岁,宫颈癌的高发年龄55~59岁。②蒙古族妇女细胞学异常(ASCUS及以上)的检出率为13.8%,(ASCUS+AGUS)6.89%、(ASC-H)1.39%、LSIL 4.51%、HSIL 0.85%、SCC 0.17%。汉族妇女细胞学异常的检出率为10.3%,(ASCUS+AGUS)5.24%、(ASC-H)1.29%、LSIL 3.14%、HSIL 0.60%、SCC 0.072%。③蒙古族妇女现患率分别为早期宫颈癌0.23%,CIN 6.82%,高度CIN(CIN II^CINⅢ)2.18%,明显高于汉族妇女。结论:①内蒙古东部地区宫颈癌现患率高发年龄段为55~59岁。②该地区蒙古族妇女宫颈癌及癌前病变现患率高于汉族妇女。Objective：To investigate the prevalence of cervical cancer and precancerous lesions among women who come to clinical visits in eastern area of Inner Mongolia,providing basic data for the clinic practice and scientific research.Method： This is a hospital-based,cross-sectional screening study.Women aged 18～69 were recruited during their routine clinical visits from May 2005 to May 2010.Thinprep cytology test was performed for each subject and those with abnormal results were performed by colposcopy,followed by biopsy if necessary.TBS system was used in this study,cytological positive results include atypical squamous cell of undetermined significance,can＇t exclude high grade squamous intraepithelial lesion（ASC-H） and higher lesions.Pathological result was the gold standard for the confirmation of cervical lesions.Result：①The highest cytological positive rate（ASC-H） was found in 25～29 age group.For SCC,HSIL and LSIL,the most prevalent age group were 55～59,45～49 and 25～29.45～49 and 40～44 gained the highest prevalence rate of CIN,but for CIN II～CIN Ⅲ and cervical cancer,the age groups with highest prevalence were 45～49 and 55-59,respectively.②For Mongolian women,the whole prevalence for abnormal cytological result（ASCUS＋） was 13.8%,including ASCUS＋AGUS（6.89%）,ASC-H（1.39%）,LSIL（4.51%）,HSIL（0.85%）and SCC（0.17%）.For Han Chinese women,whole prevalence for abnormal cytological result（ASCUS＋） was 10.3%,including ASCUS＋AGUS（5.24%）,ASC-H（1.29%）,LSIL（3.14%）,HSIL（0.60%）and SCC（0.072%）.③The prevalence of cervical cancer and cervical precancerous lesions in Mongolian women are higher than Han Chinese women,with the prevalence of early invasive carcinoma（0.23%）,CIN（6.82%）,CIN2＋（2.18%）.Conclusion： ①Women aged 55-59 gained the highest prevalence of cervical cancer and cervical precarious lesions in eastern Inner Mongolia.②In this area, the prevalence of cervical cancer and cervical precarious lesions in Mongolian wom

关 键 词：宫颈癌筛查 薄层液基细胞学 阴道镜 病理组织学 

分 类 号：R737.33[医药卫生—肿瘤]