基质金属蛋白酶-2及基质金属蛋白酶-9与卵巢上皮性癌血管生成的关系  

Angiogenesis of metalloproteinase-2 and metalloproteinase-9 in epithelial ovarian

作　　者：杨树艳[1] 杨宝丽[2] 李少华[2] 

机构地区：[1]哈尔滨医科大学第四附属医院妇科,黑龙江牡丹江150086 [2]牡丹江医学院附属医院妇产科,黑龙江牡丹江157001

出　　处：《中国现代医学杂志》2011年第22期2726-2728,共3页China Journal of Modern Medicine

基　　金：黑龙江省教育厅科学技术项目(No:11551305)

摘　　要：目的探讨基质金属蛋白酶-2(MMP-2)及基质金属蛋白酶-9(MMP-9)对卵巢上皮性癌(EOC)血管生成的影响。方法采用免疫组织化学法(SP法)检测60例卵巢上皮性癌组织中MMP-2以及MMP-9的表达,并对标本微血管密度(MVD)进行检测,与10例正常卵巢组织和16例卵巢良性肿瘤组织进行对比分析。结果卵巢上皮性癌组织及卵巢良性肿瘤中的MMP-2及MMP-9的阳性表达率显著性高于正常卵巢组织(均P<0.01);MMP-2及MMP-9在卵巢癌组织中的表达与MVD呈正相关(均P<0.05)。结论 MMP-2及MMP-9可能在卵巢上皮性癌血管生成中起重要的作用,MMP-2和MMP-9的表达增强,血管生成的能力也显著增强。【Objective】 To study the angiogenesis of matrix metalloproteinase-2（MMP-2） and matrix metalloproteinase-9（MMP-9） of epithelial ovarian cancer（EOC）.【Methods】 The expression of MMP-2 and MMP-9 in 60 cases of diagnosis and treatment of epithelial ovarian cancer patients and 10 cases of normal epithelial ovarian tissue and 16 cases of benign ovarian tumor tissue were detected by immunohistochemical method（SP）,the expression of microvessel density（MVD） was detected by the same method.【Results】 MMP-2 and MMP-9 positive expression rate in the epithelial ovarian cancer and benign ovarian tumors were significantly higher than normal ovarian tissue（both P 0.01）;MMP-2 and MMP-9 in ovarian cancer tissues and MVD were positively correlated（both P 0.05）.【Conclusions】 MMP-2 and MMP-9 may play an important role in angiogenesis of epithelia ovarian cancer,angiogenesis ability was significantly enhanced while MMP-2 and MMP-9 expression enhanced.

关 键 词：卵巢上皮性癌 基质金属蛋白酶-2 基质金属蛋白酶-9 微血管密度 

分 类 号：R737.31[医药卫生—肿瘤]