首发精神分裂症听觉感觉门控异常的功能磁共振研究  

Functional magnetic resonance imaging(fMRI) study of abnormal auditory sensory gating in first-episode schizophrenia

作　　者：卓永宁[1] 冀宾[2,3] 梅维[2,3] 马树华[2,3] 景举珍[2,3] 伍秋林[2,3] 

机构地区：[1]四汕头大学精神卫生中心,汕头515063 [2]汕头大学医学院第一附属医院 [3]广东省医学分子影像重点实验室

出　　处：《中国神经精神疾病杂志》2011年第8期464-468,共5页Chinese Journal of Nervous and Mental Diseases

基　　金：广东省科技计划项目(编号:2008B030301367);国家自然科学基金面上项目(编号:81072905)

摘　　要：目的探讨首发精神分裂症患者听觉门控异常与脑功能异常激活之间的关系。方法 11例首发精神分裂症患者及11名年龄、性别、受教育程度相匹配的正常对照进行脑功能磁共振成像,实验采用多声音刺激和单声音刺激比较的范式,以多声音刺激减单声音刺激的对比探测感觉门控的脑激活效应。以SPM2处理脑影像数据,使用两样本t检验比较两组间听觉感觉门控脑功能激活的差异。结果患者组的感觉门控脑激活在右侧海马(x=24,y=-28,z=-8,体素集合数=16)、右侧丘脑(x=8,y=-4,z=4,体素集合数=22)低于正常对照组(t=3.57,P=0.001;t=3.38,P=0.001)。结论首发精神分裂症患者的听觉门控异常可能与海马、丘脑等脑区的功能激活异常有关。Objective The present study was conducted to explore the correlation of sensory gating deficits with abnormal brain activation in the first episodic schizophrenia. Methods Eleven schizophrenia patients in the first episodic and 11 healthy controls matched in gender, age, education underwent a fMRI auditory sensory gating task. The experiments were performed using multi- and single click stimulation and the brain activation of sensory gating effects was measured using＂muhiclicks minus single click＂. The results were analyzed using SPM2 and the data from two groups were compared by two sample t-test. Results Compared with healthy controls, schizophrenia patients showed decreased activation in the right hippocampus （x = 24, y = -28, z = -8, cluster = 16 voxels, t = -3.57, P = 0.001 ） and right thalamus （x = 8, y = -4, z = 4, cluster = 22 voxels, t = -3.38, P = 0.001 ） during the fMRI sensory gating task. Conclusion Our data indicate that the abnormal brain activation in the hippocampus and thalamus may be related to the sensory gating deficits in the first- episode schizophrenia patients.

关 键 词：精神分裂症 听觉 感觉门控 功能磁共振 

分 类 号：R749.3[医药卫生—神经病学与精神病学]