云南基诺族精神分裂症患病率的30年随访研究  

The prevalence rate of schizophrenia in Jinuo ethnic group-a 30 year follow up study

作　　者：杨晓斌[1] 康传媛[1] 李秋媛[1] 刘小彦[2] 李培凯[2] 杨建中[1] 

机构地区：[1]昆明医学院第一附属医院精神科,昆明650032 [2]云南省第二人民医院临床心理科

出　　处：《中国神经精神疾病杂志》2011年第8期469-472,共4页Chinese Journal of Nervous and Mental Diseases

基　　金：国家自然科学基金(编号:30600208)

摘　　要：目的了解2009年基诺族精神分裂症的患病率和发病率,并了解其近30年的患病率变化趋势。方法 2009年对基诺族44个自然村总计10610人进行单纯整群随机抽样,对实际抽样的1984人进行精神分裂症的患病率调查。采用一般健康问卷12项(12-item general health questionnaire,GHQ-12)进行筛查,依据GHQ-12得分按比例抽取危险人群,采用SCID-I/P工具进行面检并作出诊断。同时,对有精神分裂症患病线索资料的个体进行入户访谈,其中包括既往流行病学调查中已诊断的33例精神分裂症病例。比较两种调查方法得到的精神分裂症患病率,对近30年来的精神分裂症患病率进行掊2趋势检验。结果线索调查中精神分裂症的终生和时点患病率、年发病率均高于抽样调查,但差异均无统计学意义(P>0.05)。线索调查结果显示,基诺族精神分裂症终生患病率0.37%(39/10610),时点患病率0.27%(29/10610),男性均高于女性(掊2=10.27,P<0.01;掊2=8.02,P<0.01)。近10年新发病例12例,其中近一年新发病1例,年发病率9.43/10万(1/10610)。与1979年、1989年、1999年比较,基诺族30年来的精神分裂症的终生患病率和时点患病率并无明显变化(掊2=0.18,P>0.05;掊2=0.18,P>0.05)。结论基诺族精神分裂症终生患病率及时点患病率近30年来无明显变化趋势。Objective To investigate the prevalence and incidence of schizophrenia in 2009 and to study trends in prevalence over a 30 year period in Jinuo ethnic group. Methods Simple cluster random sampling was used to selected subjects from total 10,610 population of 44 Jinuo villages in 2009. The selected 1984 people were screened using 12-item general health questionnaire （GHQ-12） and were further selected proportionally according to the scores of GHQ-12 to be interviewed by structured clinical interview for DSM-IV-TR axis I disorders-patient edition （SCID-I/P）. People with suspected schizophrenia from previous datas were interviewed, including 33 patients who were diagnosed as schizophrenia in the epidemiological investigation in 1999. The prevalence rates calculated from the above two investigation methods were compared and Chi-square trend test was used to analyze the prevalence trend during past 30 years. Results The lifetime prevalence rate and the point prevalence rate of schizophrenia in clue investigation are higher but the difference did not reach statistical significance compared with cluster sampling investigation. Clue investigation indicated the lifetime preva- lence rate and the point prevalence rate were 0.37% （39/10610） and 0.27% （29/10 610）, respectively. Lifetime prevalence rate and point prevalence rate were higher in men than in women （Х^2 = 10.27,P 〈 0.01 ; Х^2 = 8.02,P 〈 0.01 ）. There were 12 new cases during past ten years including a new case in last year. The annual incidence of schizophrenia was 9.43/ 100 000 （1/10610）. Neither the lifetime prevalence rate nor the point prevalence rate was significantly changed during past 30 years （Х^2 = 10.27, P 〈 0.01 ; Х^2 = 8.02, P〈 0.01）. Conclusion Both of the lifetime prevalence rate and the point prevalence rate of shcizophrenia in Jinuo ethnic group remain constant during past 30 years.

关 键 词：基诺族 精神分裂症 患病率随访研究 

分 类 号：R749.3[医药卫生—神经病学与精神病学] R181.32[医药卫生—临床医学]