Structural biology investigation of EMF effect on insulin in solution  

作　　者：LIU Yahui CHEN Yongbin XU Chunyan XU Shenglong SUN Bo ZHOU Huan SUN Lihua YU Feng TANG Lin GUO Guozhen HE Jianhua 

机构地区：[1]Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai 201800, China [2]Graduate University of Chinese Academy of Sciences Beijingl O0049, China [3]Department of Radiation Medicine, Fourth Military Medical University, Xi 'an 710032, China

出　　处：《Nuclear Science and Techniques》2011年第3期134-138,共5页核技术（英文）

基　　金：Supported by National Natural Science Foundation of China (No.10774155,No.30901215,No.30972430,No.30870576,No.60971055,No.31000389);Grant from Shanghai Institute of Applied Physics,Chinese Academy of Sciences(No.O95501C061 )

摘　　要：It was reported that the a-helix of protein molecules could be destroyed when they were exposed to the electromagnetic field(EMF) and finally the signal transduction could be affected.To study this effect,one signal molecule,insulin,was exposed to electromagnetic fields at different combinations of the field strength,repetition rate and exposure time.For the first time,structural biology approach was used to detect the EMF effect.The results of a series of measurements on the interaction of electromagnetic fields with insulin in vitro are described.Under our experimental conditions,no effects of electromagnetic field exposure were observed on the molecular conformation.It was reported that the ct-helix of protein molecules could be destroyed when they were exposed to the electromagnetic field （EMF） and finally the signal transduction could be affected. To study this effect, one signal molecule, insulin, was exposed to electromagnetic fields at different combinations of the field strength, repetition rate and exposure time. For the first time, structural biology approach was used to detect the EMF effect. The results of a series of measurements on the interaction of electromagnetic fields with insulin in vitro are described. Under our experimental conditions, no effects of electromagnetic field exposure were observed on the molecular conformation.

关 键 词：电磁场效应 结构生物学 胰岛素 生物学调查 蛋白质分子 溶液 信号转导 信号分子 

分 类 号：Q7[生物学—分子生物学] U674.703.3[交通运输工程—船舶及航道工程]