单一应用磷酸钠盐口服溶液在大肠癌术前肠道准备中的临床观察  

Clinical observation of single oral sodium phosphate in preoperative bowel preparation for colorectal cancer

作　　者：袁强[1] 杜峻峰[1] 陈光[1] 徐一石[1] 魏晓军[1] 孙亮[1] 苑树俊[1] 陈纲[1] 于波[1] 

机构地区：[1]解放军北京军区总医院普通外科,北京100700

出　　处：《临床军医杂志》2011年第4期785-788,共4页Clinical Journal of Medical Officers

基　　金：国家自然科学青年基金(81000189)

摘　　要：目的探讨单一应用磷酸钠盐口服溶液在大肠癌术前肠道准备中的清洁效果、不良反应和耐受性。方法将212例需做术前肠道准备的大肠癌患者随机分为四组:A组53例,口服磷酸钠盐口服溶液;B组55例,口服磷酸钠盐口服溶液联合磷酸钠盐灌肠液肛入;C组51例口服聚乙二醇电解质溶液;D组53例,口服硫酸镁溶液。观察4种不同肠道准备方法的肠道清洁有效率、不良反应率和耐受性。结果A组患者的肠道清洁有效率显著优于C组(P=0.031),而与B组、D组相比均无统计学差异(P>0.05)。A组患者在腹胀及恶心发生率方面显著低于D组(P=0.037,0.008),而在腹痛、腹胀、恶心、呕吐方面A组与B组、C组相比均无统计学差异(P>0.05)。A组患者的耐受性显著优于D组(P=0.001),而与B组、C组比较均无统计学差异(P=0.570,0.379)。结论 单一应用磷酸钠盐口服溶液用于大肠癌术前肠道准备的肠道清洁有效率高,且不良反应少,患者耐受性好。Objective To explore the cleaning efficacy,tolerability and safety of single oral sodium phosphate in preoperative bowel preparation for colorectal cancer.Methods 212 patients who underwent the operation of colorectal cancer were randomly divided into four groups： A,B,C and D.In A group,53 cases took single oral sodium phosphate.In B group,55 cases were given the combination of oral sodium phosphate and sodium phosphate clyster.51 cases took polyethylene glycol solution（PEG） in group C,and 53 cases was administrated magnesium sulfate in group D.The cleaning efficacy,tolerability and safety were evaluated after bowel preparation.Results The cleaning efficacy of A group was significantly superior to that of B group（P=0.031）,however no statistical difference was observed as compared with B or C group（P0.05）.The incidence rate of bellyache,bloating and nausea in A group were all lower than those of D group（P=0.037,0.008）.However,with regard to bellyache,bloating,nausea and vomiting,no statistical difference was observed between A group and B or C group,respectively（P0.05）.Additionally,the tolerability of A group was significantly better than that of D group,while no significant difference in contrast to B or C group,respectively（P=0.570,0.379）.Conclusion Single oral sodium phosphate as treatment of bowel preparation for colorectal cancer possesses higher efficacy,fewer adverse effect and better tolerability.

关 键 词：大肠癌手术 肠道准备 磷酸钠盐口服溶液 

分 类 号：R735.34[医药卫生—肿瘤]