大鼠第一磨牙近中移动实验动物模型的建立  

Establishment of animal model for research of first molar mesial movement in rat

作　　者：徐建光[1] 王磊[2] 贾春玲[2] 张君[2,3] 

机构地区：[1]安徽医科大学口腔医学院,安徽合肥230032 [2]山东大学齐鲁医院口腔科,山东济南250012 [3]山东大学口腔医学院,山东济南250012

出　　处：《上海口腔医学》2011年第4期373-376,共4页Shanghai Journal of Stomatology

基　　金：山东省自然科学基金(Q2008C11)

摘　　要：目的:建立近中移动大鼠第一磨牙的实验动物模型。方法:选用40只8周龄雌性SPF级Wistar大鼠,随机分为2组,2组均以2颗上颌切牙为支抗,近中移动上颌第一磨牙,其中一组采用传统矫治装置以结扎丝固定牵引磨牙,另一组采用硅橡胶,取模后制作个体化矫治装置固定牵引磨牙,分别比较2种方法第一磨牙近中移动距离、矫治装置脱落率及第一磨牙牙周情况,采用SPSS11.0软件包对数据进行统计学分析。结果:2组第一磨牙近中移动的距离之间无显著差异(P>0.05);而矫治装置脱落率及第一磨牙牙周情况在2组间存在显著差异,个体化矫治装置组矫治装置脱落率为5%,传统矫治装置组矫治装置脱落率为35%(P<0.05),个体化矫治装置组明显优于传统矫治装置组。结论:个体化矫治装置更适用于大鼠正畸牙移动,所建立的实验动物模型可用于今后大鼠牙移动的相关实验研究。PURPOSE： To establish an animal model for research of first molar mesial movement in rat.METHODS： Forty 7-weeks-old SPF female Wistar rats were chosen in this experiment,which were divided into two groups.In each group,the two central incisors were used as anchorage to move the maxillary first molars mesially.In one group,traditional orthodontic appliances was used to move the first molars,while in another group modified device was used for moving the first molars.The distance of first molar mesial movement,the drop-off rate of orthodontic appliances and the periodontal status of first molars were evaluated.The data were analyzed with SPSS 11.0 software package.RESULTS： The drop-off rate in the group of individual orthodontic appliances was 5%.The drop-off rate in the group of traditional orthodontic appliance was 35%.There was significant difference in drop-off rate of orthodontic appliances and periodontal status of first molars between the two groups.But there was no significant difference on the molar moving distance.CONCLUSIONS： Individual orthodontic appliances are more suitable for tooth movement research than traditional ones.This animal model using individual orthodontic appliances can be used in future tooth movement research.Supported by Natural Science Foundation of Shangdong Province（Q2008C11）.

关 键 词：动物模型 矫治装置 牙移动 牙周指数 

分 类 号：R783.5[医药卫生—口腔医学]