短暂性脑缺血发作后急性脑梗死患者白细胞介素-6水平的变化及临床价值  

Changes of IL - 6 in cerebral infarction after transient ischemic attacks and its clinical value

作　　者：郜旭[1] 吴秀萍[1] 田旻[1] 褚稳稳[1] 

机构地区：[1]哈尔滨医科大学第一临床医学院干部二病房,黑龙江150001

出　　处：《中国急救医学》2011年第8期694-696,共3页Chinese Journal of Critical Care Medicine

基　　金：黑龙江省科学技术计划项目（No.GC07C35203）

摘　　要：目的 探讨脑缺血预处理和他汀类药物预处理的脑保护机制.方法 60例急性脑梗死病例分为三组：脑梗死组、短暂性脑缺血发作（TIA）后脑梗死组和他汀药物治疗组.应用欧洲卒中评分（ESS）评价临床神经功能情况,利用CT片测脑卒中病灶体积,采用ELISA法对血浆白细胞介素-6（IL-6）水平进行检测.结果 在梗死后相同时间点,TIA后脑梗死组临床疗效明显优于脑梗死组,治疗后脑卒中病灶体积小于脑梗死组,IL-6水平有明显降低.在此基础上,他汀药物治疗组较TIA后脑梗死组各项指标又有进一步的改善,差异有统计学意义（P〈0.05）.结论 在临床上,TIA可诱导脑缺血耐受作用,与降低炎症细胞因子水平有关,预防性使用他汀类药物可以对严重缺血脑损伤产生明显的保护作用.Objective To study the brain protection mechanism of cerebral ischemia and statins pretreatment. Methods A total of 60 patients with acute cerebral infarction were divided into 3 groups： the patients were suffering from cerebral infarction （cerebral infarction group）, cerebral infarction after transient ischemic attacks（TIA） （cerebral infarction after TIA group ） or treated with statins （statin treatment group）. To evaluate the clinical nervous function by using ESS, to measure the focal stroke volume by CT slice and to determine the IL - 6 concentration by ELISA. Results At the same time after the infarction, clinical curative effect of patients in cerebral infarction after TIA group was obviously better than that of patients in cerebral infarction group, focal stroke volume was smaller and IL - 6 concentration was lower after the treatment. On this basis, each index of statins treatment group had further improvement, compared with cerebral infarction after TIA group. There was statistical difference between two groups（P 〈 0.05 ）. Conclusion In clinical, TIA can induce brain ischemia tolerance, which has something to do with reduction of inflammatory cytokine. Preventive use of statins has obvious protective effect for severe ischemia in brain damage.

关 键 词：短暂性脑缺血发作(TIA) 脑缺血预处理 他汀类药物 白细胞介素-6(IL-6) 

分 类 号：R743.33[医药卫生—神经病学与精神病学]