藏药八味沉香散50%醇提部位对急性心肌缺血大鼠作用的研究  

Effects of 50% Ethanol-extract from Bawei Chenxiang Powder on Acute Myocardium Ischemia Rats

作　　者：杨梅[1] 李永芳[1] 寇毅英[1] 格日力[1] 

机构地区：[1]青海大学医学院,青海西宁810001

出　　处：《新中医》2011年第9期97-99,共3页New Chinese Medicine

基　　金：青海省科技厅资助项目(编号:2005-J-801)

摘　　要：目的:研究八味沉香散50%醇提部位对垂体后叶素诱发的急性心肌缺血大鼠的作用。方法:采用大鼠舌下静脉注射垂体后叶素复制急性心肌缺血模型,实验大鼠随机分为正常对照组、模型对照组、阳性对照组、八味沉香散50%醇提液大、小剂量组。观察八味沉香散50%醇提液对大鼠注射垂体后叶素后血清乳酸脱氢酶(LDH)、肌酸激酶(CK)和心肌超微结构的影响。结果:与模型对照组比较,八味沉香散50%醇提液预处理后可明显减少大鼠血CK和LDH的释放(均P<0.01),并减轻心肌超微结构线粒体的损伤。结论:八味沉香散50%醇提液对垂体后叶素所致大鼠急性心肌缺血具有一定的保护作用,而抗心肌缺血的作用可能与其保护心肌线粒体结构,改善缺血心肌的能量代谢有关。Objective. To observe the effect of 50% ethanol-extract from Tibetan herbs of Bawei Chenxiang Powder （BCP） on pituitrin-induced experimental acute myocardial ischemia rats. Methods. Acute myocardial ischemia rat models were established by intravenous injection of pituitrin through sublingual vein. All rats were randomized into five groups： normal group, model group and positive control group, and high- and low-dose of BCP 50% ethanol-extract groups. The activity of lactate dehydrogenase（LDH） and creatine kinase（CK） in the serum were measured, and the myocardial ultrastructure of all of the rats was examined under electron microscope. Results： As compared with the model group, both high-and low-dose BCP 50% ethanol-extract could obviously decrease the serum activities of LDH and CK（P 〈 0.01）, and relieve the injury of partial mitochondria of the myocardium ofexperimental acute myocardial ischemia rats. Conclusion. The 50% ethanol-extract from Bawei Chenxiang Powder has protective effect against pituitrin-induced myocardial injury in rats by protecting the structure of mitochondria and by improving the energy metabolism of mYocardium.

关 键 词：八味沉香散 藏药 心肌缺血 垂体后叶素 线粒体 动物实验 大鼠 

分 类 号：R285.5[医药卫生—中药学]