肿瘤标记物基质金属蛋白酶9和内皮抑素鉴别良恶性胸腔积液的临床意义  

Clinical significance of matrix metalloproteinase-9 and endostatin in differential diagnosis of benign and malignant pleurai effusion

作　　者：李雪冰[1] 时广利[2] 张同梅[1] 鲁葆华[1] 宋长兴[2] 李宝兰[1] 

机构地区：[1]首都医科大学附属北京胸科医院综合科,101149 [2]首都医科大学附属北京胸科医院临床免疫室,101149

出　　处：《国际呼吸杂志》2011年第16期1208-1211,共4页International Journal of Respiration

摘　　要：目的探讨肺癌恶性胸腔积液中基质金属蛋白酶9（MMP-9）和内皮抑素（ES）的水平及其临床意义。方法采用ELISA方法，检测了176例患者胸腔积液中MMP-9和ES的含量，其中肺癌恶性胸腔积液95例，结核性胸腔积液42例，心衰所致漏出性胸腔积液39例。结果恶性胸腔积液中MMP-9和ES水平明显高于结核性胸腔积液及漏出性胸腔积液（P值均〈0．01）。肺癌患者胸腔积液MMP-9、ES水平与肿瘤组织类型有关（P〈0．05），MMP-9水平还与有无胸膜之外的远隔器官转移有关（P〈0．05）；MMP-9、ES诊断非小细胞肺癌恶性胸腔积液的敏感度分别为67．9％和82．1％，特异度分别为88．1％和64．3％。结论肺癌恶性胸腔积液中MMP-9和ES水平明显升高，提示它们参与了恶性胸腔积液的形成，二者敏感度及特异度均较高，是较好的临床诊断辅助指标。Objective To study the levels and clinical significance of matrix metalloproteinase-9 （MMP-9） and endostatin in malignant pleural effusion of non-small cell lung cancer （NSCLC） patients. Methods MMP 9 and endostatin were detected in pleural effusion of 95 patients with NSCLC by ELISA method. Results The levels of MMP-9 and endostatin in pleural effusion of NSCLC patients were significantly higher than those in patients with benign pulmonary diseases （all P %0.01）. The levels of MMP-9 and endostatin in pleural effusion of NSCLC patients were closely related to the histological classification （ P 〈0.05）. By detection of MMP-9 and endostatin,the sensitivity was 67.9% and 82.1%, the specit＇icity was 88.1 % and 64.3% for diagnosis of malignant pleural effusion. Conclusions MMP-9 and endostatin were significantly increased in pleural effusion of NSCLC patients. They had high sensitivity and specificity.

关 键 词：非小细胞肺癌 基质金属蛋白酶9 内皮抑素 胸腔积液 

分 类 号：R734.2[医药卫生—肿瘤]