缺血性脑血管病动物模型研究概况与中药药效学评价思考  

Overview in establishing animal models against ischemic cerebrocardiac disease and thinking about efficacy evaluation of traditional Chinese medicine

作　　者：孙蓉[1] 张亚囡[2] 

机构地区：[1]山东省中医药研究院,山东济南250014 [2]山东中医药大学,山东济南250355

出　　处：《中国中药杂志》2011年第16期2299-2302,共4页China Journal of Chinese Materia Medica

基　　金：国家"重大新药创制"科技重大专项(2009ZX09502-015);山东省重大新药创制综合性大平台项目(2009ZX09301-013);山东省博士后创新项目(200801002)

摘　　要：为了探究缺血性脑血管病的病理机制、药物筛选、药效评价、治疗方案优化,目前建立了许多模拟人类脑缺血疾病的实验动物模型。如何根据中药自身的特点选择合适的动物模型,进行候选药物筛选和药效评价,并将脑缺血动物模型的研究与临床疾病研究紧密地结合起来,保证动物模型的稳定性和可靠性,以对临床前中药药理研究与药效评价的有效药物,在临床上获得更好的疗效,提供方法学保证和有效的中药创新药物筛选与研发评价的研究工具。In order to explore the pathogenesis of ischemic cerebrovascular disease,drug screening,efficacy evaluation and treatment plan optimization,many kinds of animal models against ischemic cerrebrocardiac were established with operation successively in recent years.According to the characteristic of traditional Chinese medicine,it′s a question to choose the appropriate animal model for drug screening and efficacy evaluation,and to combine the cerebral ischemia of animal models with clinical disease research closely.The stability and reliability of animal models and the efficacy of drugs in clinical should be considered in order to provide effective drug screening evaluation research tools.

关 键 词：缺血性脑血管病 药效评价 动物模型 

分 类 号：R-332[医药卫生]