齐拉西酮与奋乃静治疗老年精神分裂症对照研究  

Control study of Zirasidone and Perphenazine in the treatment of senile schizophrenia

作　　者：崔明伟[1] 

机构地区：[1]天津市安宁医院,天津300000

出　　处：《中国民康医学》2011年第16期1970-1970,2055,共2页Medical Journal of Chinese People’s Health

摘　　要：目的:探讨齐拉西酮治疗老年精神分裂症的疗效及安全性。方法:将48例患者随机分为两组,齐拉西酮组24例,奋乃静组24例。采用阴性与阳性症状量表(PANSS)和副反应量表(TESS),于治疗前及治疗后的第2、4、6、8周末各评定1次,评定疗效和不良反应。结果:齐拉西酮对老年精神分裂症有效(P均<0.01),不良反应明显少于奋乃静组,尤以锥体外系副反应明显少于奋乃静组(P<0.05)。结论:齐拉西酮具有起效快、安全性好、不良反应少的特点,可作为老年精神分裂症的首选药物。Objective：To explore the efficacy and safety of Zirasidone in the treatment of senile schizophrenia.Methods：48 patients were randomly divided into Zirasidone group（n=24） and Perphenazine group（n=24）.The positve and negative syndrome scale（PANSS） and treatment emergent symptoms scale（TESS） were used to evaluate efficacy and adverse effects respectively before and at the end of 2,4,6,8 week of treatment.Results：Zirasidone is effective for senile schizophrenia（P〈0.01）,Ziprasidone had less effect than Perphenazine（P〈0.05）.Conclusion：Ziprasidone has good safety,action fast and few adverse reactions,can be used as the first choice of teatment for senile schizophrenia.

关 键 词：齐拉西酮 奋乃静 老年精神分裂症 

分 类 号：R749.3[医药卫生—神经病学与精神病学]