结肠癌中Notch-1与ki-67的表达及临床意义  

Expression of Notch-1 andki-67 protein in human colorectal cancer and it's significance

作　　者：何晓彬[1] 赖敏[1] 

机构地区：[1]泸州医学院附属医院消化内科,四川泸州646000

出　　处：《四川医学》2011年第8期1178-1180,共3页Sichuan Medical Journal

摘　　要：目的探讨Notch-1与ki-67在结肠癌组织中的表达及其与临床病理的关系。方法应用免疫组织化学SP法检测结肠癌组织中Notch-1与ki-67蛋白的表达,并分析Notch-1与ki-67蛋白表达与临床病理参数的关系。结果 Notch-1与ki-67蛋白在结肠癌中表达的阳性率明显高于正常组织(P<0.05);Notch l阳性表达与患者的性别、年龄、淋巴转移及远处转移均无明显相关性(P>0.05),而与肿瘤大小、分化程度显著相关(P<0.01或P<0.05);Ki-67表达与组织学类型无关,但与癌细胞分化程度及淋巴结转移有关,分化程度越低、伴有淋巴结转移者Ki-67表达越强(r=0.355、0.385,P均<0.05)。结肠癌中Notch-1蛋白与ki-67蛋白表达呈正相关(r=0.305,P<0.05)。结论 Notch-1蛋白可能在结肠癌发生发展中起重要作用。ki-67对结肠癌的早期发现及诊断有重要意义。Objective To discusses the expression of Notch-1 and ki-67 in human colorectal cancer（CRC） and the relationship with clinical pathology.Methods Immunohistochemistry SP method was used to utilize the expressions of Notch l and ki-67 protein in CRC,and the relationship with the clinic pathology were analyzed.Results The positive expression rates of Notch l and ki-67 protein in CRC were higher than those in normal colon tissues（P0.05）.The positive expression of Notch-l has obviously non-correlation with gender,age,lymph node metastasis and distant metastasis of patients（P0.05）.It was closely associated with magnitude and differentiation of tumor（P0.01 or P0.05）.The expression of Ki-67 has no relatimship with histology category.It was closely associated with differentiation of tumor and lymph node metastasis.The higher expression of Ki-67 associated with poorly differentiated and metaptosis（r=0.355、0.385 and P 0.05）.There was positive correlation between the expressions of Notch1 and ki-67 protein in CRC（r=0.305,P0.05）.Conclusion Notch l protein may play an important role in the pathway of carcinogenesis and progression of CRC.Ki-67 have an important significance to early discovery and diagnose of CRC.

关 键 词：NOTCH-1 KI-67 免疫组织化学 结肠癌 

分 类 号：R735.35[医药卫生—肿瘤]