对克拉霉素与阿莫西林耐药的幽门螺杆菌感染患者的临床治疗观察  

Clarithromycin and Amoxicillin-resistant Helicobacter Pylori Infection in Patients with Clinical Observation

作　　者：张文礼[1] 李永春[1] 

机构地区：[1]宜宾市第一人民医院,四川宜宾644000

出　　处：《亚太传统医药》2011年第8期78-79,共2页Asia-Pacific Traditional Medicine

摘　　要：目的:对克拉霉素和阿莫西林耐药的幽门螺杆菌(Hp)感染者治疗方案进行比较,探讨行之有效的治疗方案。方法:回顾性分析260例幽门螺杆菌感染者的不同治疗方案的治疗结果。入选患者分别接受质子泵抑制剂(奥美拉唑肠溶胶囊20mg,2次/d)+左氧氟沙星胶囊(0.2,2次/d)+呋喃唑酮(0.1,2次/d)和质子泵抑制剂(奥美拉唑肠溶胶囊20mg,2次/d)+甲硝唑(0.2,2次/d)+庆大霉素针(8万U,2次/d,口服)的两周治疗,一个月后内镜下在胃窦、胃体两点复查快速尿素酶试验。结果:左氧氟沙星组Hp清除率为74.65%(109/146),甲硝唑组43.85%(50/114),两组Hp清除率比较差异有统计学意义(P<0.05)。结论:质子泵抑制剂+左氧氟沙星胶囊+呋喃唑酮杀菌率高,不良反应小,建议作为继克拉霉素组合之后的二线首选组合药物。Objective：to clarithromycin and amoxicillin-resistant Helicobacter pylori（Hp）infection in treatment options,and compare to find more effective treatment.Methods：Retrospective analysis of 260 patients with Helicobacter pylori infection in different treatment outcomes.Selected patients received proton pump inhibitors（omeprazole capsules 20mg,2times/d）＋levofloxacin capsules（0.2,2 times/d）＋furazolidone（0.1,2 times/d）and proton pump inhibitors（omeprazole capsule 20mg,2times/d）＋metronidazole（0.2,2 times/d）＋gentamicin needle（80,000 U,2 times/d,orally）in two weeks of treatment,a months after the endoscopic review by rapid urease test（antrum,gastric body points）.Results：Hp eradication rate of levofloxacin group 74.65%（109/146）,metronidazole group 43.85%（50/114）,compared two groups of Hp clearance rate was significantly（P0.05）.Conclusion：Proton pump inhibitors＋capsule＋furazolidone Levofloxacin bactericidal rate,adverse reactions,it is proposed as a combination of clarithromycin after following the second preferred combination.

关 键 词：幽门螺杆菌 阿莫西林 克拉霉素 耐药 左氧氟沙星 呋喃唑酮 

分 类 号：R573.6[医药卫生—消化系统]