小剂量尿激酶溶栓治疗急性脑梗死临床观察  

Intravenous thrombolysis with low dose urokinase for acute cerebral infarctions

作　　者：孙高慧[1] 高志强[1] 高俊风[1] 贾鹏[1] 

机构地区：[1]南京医科大学第二附属医院神经内科,南京210011

出　　处：《中国实用神经疾病杂志》2011年第16期12-14,共3页Chinese Journal of Practical Nervous Diseases

摘　　要：目的观察尿激酶静脉溶栓治疗急性脑梗死的临床有效性及安全性。方法应用小剂量尿激酶超早期（发病6h内）静脉溶栓治疗急性脑梗死19例，于溶栓前及溶栓后24h、10d进行神经功能缺损及日常生活指数量表评分，同时观察脑内及其他系统有无出血并发症。结果溶栓后24h神经功能缺损及日常生活指数评分与溶栓前相比均有改善，P〈0．05；lOd后神经功能缺损及日常生活指数评分与溶栓前相比进一步改善，P〈O．01；发病3h内溶栓组与3～6h溶栓组在10d时相比，前者溶栓痊愈率及有效率均高于后者。本组无1例有脑内及其他系统出血等并发症。结论小剂量尿激酶静脉溶栓治疗急性脑梗死其疗效较肯定，溶检开始时间越早，疗效越好，应用比较安全。Objective To evaluate the clinical efficacy and safety of urokinase（UK）in the treatment of acute cerebral in- farctions. Methods Nineteen cases of acute cerebral infarction were treated by intravenous thrombolysis with low dose UK, and the scores of National Institutes of Health Stroke Scale（NIHSS） about neurological deficits and Barthel index about daily life before thrombolysis and 24 hours, 10 days after thrombolysis were calculated, while observing whether brain and other sys- tems had bleeding complications or not. Results There was a significant difference on NIHSS and Barthel index scores before and after thrombolysis. NHISS and Barthel index scores of 24 hours after thrombolysis were significantly improved than before （P〈0.05）, the scores of 10 days after thrombolysis were further significantly improved than before（P〈0.01）. Compared with the 3-6 hours thrombolysis group, the recovery and efficient rate were higher than the 3 hours group at the 10th day. No case appeared brain bleeding. Conclusion Intravenous thrombolysis therapy with low dose urokinase is one of the safe and effective choices for acute cerebral infarction. The earlier of the thrombolysis, thq better of curative effect.

关 键 词：脑梗死 溶栓 尿激酶 

分 类 号：R743.33[医药卫生—神经病学与精神病学]