Fe_3O_4 Magnetic Nanoparticles Modified Electrode as a Sensor for Determination of Nimesulide  

作　　者：ZHANG Jin-lei TAN Xue-cai ZHAO Dan-dan TAN Sheng-wei LIU Li WANG Lin HUANG Zeng-wei 

机构地区：[1]College of Chemistry and Ecological Engineering, Guangxi University for Nationalities, Nanning 530006, P. R. China [2]Department of Chemistry and Life Science, Baise University, Baise 533000, P. R. China

出　　处：《Chemical Research in Chinese Universities》2011年第4期566-569,共4页高等学校化学研究（英文版）

基　　金：Supported by the National Natural Science Foundation of China(No.21065001);the Natural Science Foundation of Guangxi Province,China(Nos.0639025,0991084);the Support Program for 100 Young and Middle-aged Disciplinary Leaders in Higher Education Institutions of Guangxi Province,China(No.RC20060703005);the Project of Key Laboratory of Development and Application of Forest Chemicals of Guangxi Province,China(No.GXFC08-06);the Fund of Education Department of Guangxi Province,China(No.200812MS074)

摘　　要：A novel type of Fe3O4 nanoparticles modified glass carbon electrode（Fe3O4/GCE） was constructed and the electrochemical properties of N-（4-nitro-2-phenoxyphenyl）methanesulfonamide（nimesulide） were studied on the Fe3O4/GCE.In 0.4mol/L HAc-NaAc buffer solution（pH=5.0）,the electrode process of nimesulide was irreversible at bare GCE and Fe3O4/GCE.The Fe3O4/GCE exhibited a remarkable catalytic and enhancement effect on the reduction of nimesulide.The reduction peak potential of nimesulide shifted positively from-0.683 V at bare GCE to-0.625 V at Fe3O4/GCE,and the sensitivity was increased by ca.3 times.Some experimental conditions were optimized.The linear range between the peak current and the concentration of nimesulide was 2.6×10-6 ＂1.0×10-4mol/L（R=0.993） with a detection limit of 1.3×10-7mol/L.This method has been used to determine the content of nimesulide in medical tablets.The recovery was determined to be 96.9% ＂101.9% by means of standard addition method.The method is comparable to UV-Vis spectrometry.A novel type of Fe3O4 nanoparticles modified glass carbon electrode（Fe3O4/GCE） was constructed and the electrochemical properties of N-（4-nitro-2-phenoxyphenyl）methanesulfonamide（nimesulide） were studied on the Fe3O4/GCE.In 0.4mol/L HAc-NaAc buffer solution（pH=5.0）,the electrode process of nimesulide was irreversible at bare GCE and Fe3O4/GCE.The Fe3O4/GCE exhibited a remarkable catalytic and enhancement effect on the reduction of nimesulide.The reduction peak potential of nimesulide shifted positively from-0.683 V at bare GCE to-0.625 V at Fe3O4/GCE,and the sensitivity was increased by ca.3 times.Some experimental conditions were optimized.The linear range between the peak current and the concentration of nimesulide was 2.6×10-6 ＂1.0×10-4mol/L（R=0.993） with a detection limit of 1.3×10-7mol/L.This method has been used to determine the content of nimesulide in medical tablets.The recovery was determined to be 96.9% ＂101.9% by means of standard addition method.The method is comparable to UV-Vis spectrometry.

关 键 词：Fe3O4 nanoparticle Modified electrode NIMESULIDE DETERMINATION Electrochemical behavior 

分 类 号：O657.1[理学—分析化学] TQ460.72[理学—化学]