序贯疗法治疗幽门螺杆菌感染患者疗效观察  

The clinical observation of sequential therapy for patients with Helicobacter pylori infection

作　　者：徐惠明[1] 陈小芳[1] 王建生[1] 周明霞[1] 张群雄[1] 

机构地区：[1]江苏省吴江市第二人民医院消化内科,215221

出　　处：《中国实用医药》2011年第22期46-47,共2页China Practical Medicine

摘　　要：目的观察序贯疗法治疗幽门螺杆菌(HP)感染患者的疗效。方法经胃镜检查确诊的慢性胃炎或消化性溃疡且HP阳性患者82例随机分为治疗组和对照组。治疗组(42例)方案为前5d奥美拉唑+阿莫西林,后5d奥美拉唑+克拉霉素+替硝唑;对照组(40例)三联疗法为奥美拉唑+阿莫西林+克拉霉素,疗程7d。结果治疗组Hp根除率92.85%,对照组Hp根除率75.00%,2组比较差异有统计学意义(P<0.05)。结论以奥美拉唑、阿莫西林、克拉霉素、替硝唑组成的10d序贯疗法治疗Hp感染较7d三联疗法有更高的根除率,可提高临床疗效。Objective To study the effects of sequential therapy for H.pylori eradication.Methods 82 patients with HP positive chronic gastritis and peptic ulcer were randomly divided into two groups.42 patients were treated with Omeprazole,Amoxillin at first five days,Omeprazole,Clarithromycin and Tinidazole at the second five days.The control group（40 patients）were treated with Omeprazole,Amoxillin and Clarithromycin for seven days.Results The eradication rate of 10 d sequential therapy was 92.85%,and that of control group was 75.00%.The difference between two groups was significant（P0.05）.Conclusion The sequential therapy is more efective and better treatment for H.pylori eradication.

关 键 词：序贯疗法 幽门螺杆菌 慢性胃炎 消化性溃疡 

分 类 号：R57[医药卫生—消化系统]