肝内胆管腺瘤临床病理观察  

Clinicopathologic characteristcs of bile duct adenoma

作　　者：李剑[1,2,3] 左敏[1,2] 彭树松[1,2] 赖美娜[1,2] 李红[1,2] 王晓玫[1,2] 

机构地区：[1]暨南大学第二临床学院 [2]深圳市人民医院病理科,广东深圳518000 [3]北京大学深圳医院病理科

出　　处：《诊断病理学杂志》2011年第4期272-275,共4页Chinese Journal of Diagnostic Pathology

摘　　要：目的探讨肝内胆管腺瘤的临床特征、组织来源、病理特点及鉴别诊断。方法观察1例肝内胆管腺瘤的组织形态与免疫组化标记,并结合文献复习。结果肿瘤直径1 cm。镜下见密集排列的分化成熟的小胆管被增生的纤维组织分隔,伴钙化及淋巴细胞浸润。免疫组化:CD56,CK19和CK7(+),Ki-67和p53(-);酸性黏液染色(+)。结论肝内胆管腺瘤罕见,可能来源于胆管周围腺体,病变本质是对局部损伤的反应。临床需与胆管错构瘤、胆管腺纤维瘤、肝内胆管细胞癌等病变相鉴别。Objective To elucidate the clinicopathologic features,histogenesis and differential diagnosis of bile duct adenoma.Methods The histological changes were depicted in a case of bile duct adnoma,and the related literatures were reviewed.Results The lesion was 1 cm in diameter.Microscopically,it was composed of densely-packed small ductules,which were separated by hyalinized fibrosis with lymphocytic infiltration on the periphery and calcification in the centre.The tumor cells showed positive staining of Alucin blue,CD56,CK19 and CK7,but negative for Ki-67 and p53.Conclusion Bile duct adenoma is a rare tumor and probably derives from peribiliary gland,which may represent a response to local injury.The distinction from bile duct hamartoma,biliary adenofibroma and cholangiocarcinoma should be cautioned in the differential diagnosis.

关 键 词：胆管腺瘤 病理 鉴别诊断 

分 类 号：R736.1[医药卫生—肿瘤]