肝纤维化中星状细胞促血管生成分子机制的研究  

Molecular basis of hepatic stellate cell-driven angiogenesis implicated in liver fibrosis

作　　者：张峰[1] 魏东华[2] 孔德松[1] 张晓平[1] 陆茵[1,3] 王爱云[1,3] 陈文星[1,3] 郑仕中[1,3] 

机构地区：[1]南京中医药大学药学院,江苏南京210029 [2]哈尔滨医科大学大庆校区药学院,黑龙江大庆163319 [3]南京中医药大学,江苏省中药药效与安全性评价重点实验室,江苏南京210046

出　　处：《中国药理学通报》2011年第9期1189-1192,共4页Chinese Pharmacological Bulletin

基　　金：国家自然科学基金资助项目(No30873424);江苏省自然科学基金资助项目(NoBK200856);江苏省针灸学重点实验室开放课题资助项目(NoKJA200801);教育部博士点博导基金资助项目(No20103237110010);江苏省六大人才基金资助项目(No2009-B-010);江苏高校优势学科建设工程资助项目

摘　　要：肝纤维化进程中存在明显的病理性血管生成与重构,阻碍了肝纤维化的逆转与恢复。血管生成及其信号调控系统已成为肝纤维化治疗的潜在靶标,血管生成抑制剂在一些实验研究中已显示出较好的抗肝纤维化疗效。肝星状细胞是肝脏中的周细胞,可以表达血管内皮生长因子、血小板衍生生长因子、瘦素、血管生成素-1等多种血管生成因子,多途径地促进病理性血管生成过程。该文对近年来肝星状细胞促进肝纤维化血管生成分子机制的研究作一综述,可以为抗肝纤维化研究提供新的视角,有助于发现新的治疗靶标。Hepatic fibrogenesis coexists with pathological angio- genesis and vascular remodeling, constituting barriers to fibrosis regression and recovery. Angiogenesis has been emerging as a potential therapeutic target for liver fibrosis, and several antian- giogenic agents have indeed exhibited antifibrotic profiles in pre- clinical studies. Hepatic stellate cells as liver specific pericytes modulate multiple stages of liver pathological angiogenesis by ex- pressing a number of proangiogenic cytokines including vascularendothelial growth factor, platelet-derived growth factor, leptin and angiopoietin-1. This review highlights the molecular mecha- nisms of fibrotic angiogenesis driven by stellate cells in the hope of providing new insight into hepatic fibrogenesis beneficial to the discovery of novel pharmacological targets.

关 键 词：肝纤维化 血管生成 肝星状细胞 血管内皮生长因子 血小板衍生生长因子 瘦素 血管生成素-1 

分 类 号：R05[医药卫生] R322.47