抑郁症的治疗研究进展  

Research progress in treatment of depression

作　　者：刘佳莉[1,2] 苑玉和[1] 陈乃宏[1] 

机构地区：[1]中国医学科学院北京协和医学院药物研究所,北京100050 [2]天津中医药大学,天津300193

出　　处：《中国药理学通报》2011年第9期1193-1196,共4页Chinese Pharmacological Bulletin

基　　金：国家自然科学基金资助项目(No30973887;81073078;81073130);国家自然科学基金广东自然科学联合基金资助项目(NoU0832008);国家创新药物重大专项资助项目(No2008ZX09101;2009ZX09303;2009ZX09301;2009ZX09303)

摘　　要：抑郁症以持续情绪低落和认知功能障碍为主要临床特征,包括焦躁情绪、快感缺失、睡眠障碍、负罪感和反复自杀念头等。抑郁症不仅给患者带来精神上的损失,也给患者造成沉重的经济负担。该文结合抑郁症相关假说:单胺假说、应激假说、神经营养因子和神经元新生假说等,根据不同的发病机制和作用通路,对抑郁症治疗进展进行综述和展望。Depression is characteristic with sustained depressive mood and cognitive dysfunction in the clinic, including restless- ness, anhedoina, sleep disorders, guilt and repeated thoughts of suicide and so on. Depression not only damages the mentality of patients, bu also brings a heavy financial burden to patients. Based on the depression-related hypothesis：the monoamine hy-pothesis, stress hypothesis, neurotrophic factors and neurogenesis hypotheses etc. , and from different mechanisms and signal path- was, we reviewed the progress of the treatment of depression.

关 键 词：抑郁症 机制 受体 神经营养因子 神经再生 药物治疗 

分 类 号：R05[医药卫生] R749.420.5