Ⅳ型胶原蛋白、层黏连蛋白在鼻腔鼻窦恶性肿瘤中表达的相关性研究  

The significance of the expression of Col Ⅳ and LN in nasal and paranasal sinus malignant tumor

作　　者：莫天石 山艳春[2] 贾海英[2] 张涛[2] 王继群 

机构地区：[1]仁伯爵医院耳鼻咽喉-颈面外科 [2]暨南大学附属第一医院耳鼻咽喉头颈外科

出　　处：《临床耳鼻咽喉头颈外科杂志》2011年第17期771-774,共4页Journal of Clinical Otorhinolaryngology Head And Neck Surgery

基　　金：澳门科研基金委员会资助课题(No:029/2009/A);广东省自然科学基金资助课题(No:9451063201003299)

摘　　要：目的:初步探讨Ⅳ型胶原蛋白(ColⅣ)、层黏连蛋白(LN)在鼻腔鼻窦恶性肿瘤中表达的相关性。方法:用免疫组织化学法检测137例鼻腔鼻窦恶性肿瘤、78例癌旁组织和37例对照组中ColⅣ和LN的表达。结果:ColⅣ和LN在鼻腔鼻窦恶性肿瘤、癌旁组织和对照组中的表达差异有统计学意义(P<0.01),在不同病理类型鼻腔鼻窦恶性肿瘤中的表达差异无统计学意义(P>0.05)。结论:ColⅣ和LN对鼻腔鼻窦恶性肿瘤的发生、发展起一定作用,在不同病理类型鼻腔鼻窦恶性肿瘤中可能发挥相似作用,无组织特异性。Objective：To study the pathological relationship between the expression of ColⅣ and LN in nasal and paranasal sinus malignant tumor（NPMT）.Method：The immunohistchemical technique was used to detected the expression of ColⅣ and LN in NPMT,para-cancer tissues and non-cancer tissues.Result：There was a significance on the expression of the ColⅣ and LN in NPMT,para-cancer tissues and non-cancer tissues（P0.01）,and no significance in endepidermis and soft connective tissue of the NPMT（P0.05）.Conclusion：The ColⅣ and LN perhaps participate in tumorigenesis of NPMT,and may play the homoioplastic role in different patholoigical types of the NPMT.

关 键 词：Ⅳ型胶原蛋白 层黏连蛋白 细胞外基质 基膜 鼻窦肿瘤 

分 类 号：R739.6[医药卫生—肿瘤]