介孔二氧化硅微球的淀粉复合止血敷料  

Mesoporous silicon dioxide microsphere/starch composite hemostatic dressing

作　　者：王立群[1] 徐磊[2] 王树伟[3] 苏佳灿[4] 

机构地区：[1]唐山工人医院妇产科,河北省唐山市063000 [2]唐山市第九医院中西医科,河北省唐山市063000 [3]唐山工人医院呼吸内科,河北省唐山市063000 [4]解放军第二军医大学附属长海医院骨科,上海市200433

出　　处：《中国组织工程研究与临床康复》2011年第29期5379-5383,共5页Journal of Clinical Rehabilitative Tissue Engineering Research

基　　金：河北省唐山市科学技术研究与发展计划项目(05134609a);上海市人事局人才发展基金(2009003);上海市博士后基金(11R21412700);中国博士后基金面上(20100470756)~~

摘　　要：背景:止血是外伤急救的重要环节。目的:研制一种新型的介孔二氧化硅微球/淀粉复合止血敷料,并观察其止血效果。方法:采用溶胶-凝胶法,以三嵌段共聚物pluronic(P123)为模板剂,合成孔径在5nm左右的介孔氧化硅微球,将其与淀粉复合,制备介孔氧化硅微球/淀粉复合止血敷料,通过动物实验观察复合材料的止血性能。结果与结论:介孔氧化硅微球/淀粉复合材料不仅具有很强的吸水性能,而且还具有明显的体外凝血性能,能显著地缩短部分凝血活酶时间和凝血酶原时间。介孔氧化硅微球/淀粉复合材料能够阻止兔背部皮肤及肝脏伤口的流血和缩短其流血时间,具有明显的止血效果。BACKGROUND： Wound bleeding is an important part of traumatism first aid. OBJECTIVE： To develop a novel mesoporous silicon dioxide microsphere/starch composite hemostatic dressing and to study its hemostatic properties. METHODS： A hemostatic dressing of mesoporous silicon dioxide microsphere/starch composite was synthesized by using pluronic （P123） as templates and sol-gel process, and its hemostatic properties were also investigated. The mesoporous silicon dioxide microsphere had large surface area and pore diameter of around 5 nm. RESULTS AND CONCLUSION： The mesoporous silicon dioxide microsphere/starch composite had good water adsorption properties as compared with mesoporous silicon dioxide and silicon dioxide （S）. The mesoporous silicon dioxide microsphere/starch composite could significantly short the partial thromboplastin time and prothrombin time. The mesoporous silicon dioxide microsphere/starch composite could shorten the bleeding time of skin and liver wound of rabbits, and control hemorrhage, showing good hemostatic properties.

关 键 词：介孔氧化硅微球 淀粉 创伤 止血敷料 兔 

分 类 号：R318[医药卫生—生物医学工程]