NF-κB在某些心血管疾病中的作用  

The role of NF-κB in some cardiovascular diseases

作　　者：王丹阳[1] 朱广瑾[1] 徐成丽[1] 

机构地区：[1]中国医学科学院基础医学研究所北京协和医学院基础学院生理学与病理生理学系,北京100005

出　　处：《基础医学与临床》2011年第9期1070-1073,共4页Basic and Clinical Medicine

摘　　要：核因子-κB(NF-κB)作为一种重要的转录因子在通常情况下对心肌细胞起保护作用,但在不同的刺激下,NF-κB表现出的作用不尽相同。NF-κB参与心血管疾病病理过程的多个环节,包括细胞生存、增殖和分化,调节细胞对各种刺激的反应,如低氧、压力和缺血等。NF-κB在众多心血管疾病如动脉粥样硬化、心肌缺血再灌注损伤、缺血预处理、心肌肥大和心力衰竭等的发生和发展中发挥重要作用。Nuclear factor-kappa B（NF-κB） acts as one kind of important transcription factors to play the protective function to the myocardial cell in physiological state,but the function of NF-κB is different based on stimulation.NF-κB has been shown to influence multiple segments during the numerous cardiovascular diseases pathological process,including cell survival,appreciation and differentiation,adjustment of cell response to each kind of stimulations,such as hypoxia,pressure and ischemia and so on.NF-κB plays an important role in numerous cardiovascular diseases such as atherosclerosis,the myocardial ischemia reperfusion injury,the ischemic preconditioning,the myocardial hypertrophy and the heart failure.

关 键 词：核因子-ΚB 低氧 内皮细胞 心血管疾病 

分 类 号：R363[医药卫生—病理学]