新跨膜蛋白非转移性黑色素瘤糖蛋白B在前列腺癌组织中的表达及意义  

Expression of glycoprotein non-metastatic melanoma protein B in prostate cancer and its significance

作　　者：萧云备[1] 乔正国[2] 张晓威[1] 刘振华[1] 谢京[1] 郝一昌[1] 郁卫东[2] 徐涛[1] 王晓峰[1] 

机构地区：[1]北京大学人民医院泌尿外科,北京100044 [2]北京大学人民医院中心实验室,北京100044

出　　处：《北京大学学报（医学版）》2011年第4期496-499,共4页Journal of Peking University:Health Sciences

摘　　要：目的:探讨非转移性黑色素瘤糖蛋白B(glycoprotein non-metastatic melanoma protein B,GPNMB)在前列腺癌组织中的表达及其临床意义。方法:应用组织芯片结合免疫组织化学方法,检测GPNMB在63例前列腺癌组织、3例异型生前列腺组织、8例良性前列腺增生组织中的表达情况,用积分光密度值(integral optical density,IOD)代表阳性细胞的表达水平。结果:GPNMB在前列腺良性增生组表达水平(IOD=70 017.49)明显低于异型增生组(IOD=10 1547.33),两组差异具有统计学意义(P=0.000 1);前列腺癌组中GPNMB的表达(IOD=162 027.54)明显高于非肿瘤组(包括良性增生和异型增生,IOD=79 290.97),两组差异具有统计学意义(P=0.000 1),但未见GPNMB的表达随着病理分级的升高而升高,病理分级低组(病理分级Ⅱ及Ⅱ以下)GPNMB表达(IOD=177 944.30)反而高于病理分级高组(病理分级Ⅱ以上,IOD=150 885.81),两组差异具有统计学意义(P=0.013)。结论:GPNMB在前列腺癌组织中的异常高表达,可能在前列腺癌的早期诊断上具有重要参考价值。Objective： To investigate the expression of glycoprotein non-metastatic melanoma protein B（GPNMB） in prostate cancer and its clinical significance.Methods：The expression of GPNMB was analysed in 63 prostate cancer and 3 heterosexual hyperplasia prostate tissue and 8 benign prostatic hyperplasia samples by immunohistochemical staining,with integral optical density（IOD） value representing expression level of positive cells.Results：The expression of GPNMB was lower in benign prostatic hyperplasia（BPH,IOD= 70 017.49） than in Atypical hyperplasia（IOD= 101 547.33,P=0.000 1）.The expression of GPNMB in tumor（IOD= 162 027.54）was higher than in non-tumor group（IOD=79 290.97）,which included BPH and atypical hyperplasia（P=0.000 1）.But GPNMB expression le-vel was not positively elevated with degree of malignancy of prostate cancer.However,the expression of GPNMB in low pathological grading（IOD=177 944.30） was higher than that in high pathological gra-ding（IOD= 150 885.81,P=0.013）.Conclusion：The abnormal expression of GPNMB may play an important role in the development of prostate cancer and its detection may be useful for the early diagnosis of prostate cancer.

关 键 词：前列腺肿瘤 膜糖蛋白类 免疫组织化学 

分 类 号：R737.25[医药卫生—肿瘤]