生物性多孔碳酸化羟基磷灰石支架的制备  

Synthesis and Characterization of a Novel Bioabsorbable Porous Carbonated Hydroxyapatite Ceramic

作　　者：战策[1] 陈建荣[1] 石川邦夫[2] 张磊[1] 

机构地区：[1]同济大学口腔医学院修复科,上海200072 [2]九州大学齿学部

出　　处：《口腔颌面外科杂志》2011年第4期247-250,共4页Journal of Oral and Maxillofacial Surgery

基　　金：上海市科学技术委员会浦江人才项目(10PJ1410500)

摘　　要：目的:研发新型生物吸收性碳酸化羟基磷灰石(CHA)支架材料。方法:Ca(OH)2粉末与不同质量比水溶性造孔剂(NaCl颗粒)充分混合,模具压缩成型,经二氧化碳气体碳酸化10 d,蒸馏水浸泡去除水溶性填料后置磷酸钠缓冲溶液磷酸化2周,得到多孔性材料。对其以扫描电镜(SEM)、X线衍射仪(XRD)、傅立叶变换红外光谱仪(FTIR)、拉伸强度测定仪、CHN元素分析进行表征。结果:本实验制得的多孔性产物,经SEM、XRD、FTIR、CHN分析表征,确定为多孔CHA,其碳酸根含量与天然骨相近。不同NaCl添加量制得的CHA气孔率不同。结论:本实验成功构建了孔隙率可调控的、与天然骨碳酸根含量相似的三维多孔CHA,该材料有望成为良好的生物吸收性支架材料。Objective： This study was aimed to develop a novel bioabsorbable carbonated hydroxyapatite scaffold material. Methods： Ca （OH）2 powder and NaCl particles were mixed and compressed within a stainless steel mold. The compacts were placed in airtight containers and supplied with carbon dioxide gas for 10 days, then immersed into distilled water to remove water-soluble fillers. At last, samples were soaked into sodium phosphate buffer solution for 2 weeks to get final porous products. Samples were characterized by scanning electron microscopy （SEM）, X-ray diffraction analysis （XRD）, Fourier transformed infrared spectroscopy （FTIR）, diametric tensile strength measurement, and CHN analysis. Results： The final porous product was proved to be carbonated hydroxyapatite （CHA） as examined by XRD, FTIR, and CHN analysis. The carbonate content was revealed to be close to human bone. Different amount of extra NaC1 could lead to various porosities. Conclusion： Porous CHA with the carbonate content similar to human bone can be fabricated from Ca （OH）2/NaC1 complex step by step, such as carbonation, washing, and phosphorylation. This porous CHA is a promising bioresorbable scaffold and thus will make a potentially success clinical contribution to bone tissue engineering.

关 键 词：人工骨 碳酸化羟基磷灰石 生物吸收性 多孔性 

分 类 号：R782[医药卫生—口腔医学] R318.08[医药卫生—临床医学]