RIP3在淋巴瘤患者病理组织中的表达  

The Expression of Receptor Interaction Protein-3 in Lymphoma Patients Pathology Organization

作　　者：任建鸿 郑文[1,2,3] 谢彦[1,2,3] 崔建涛[1,2,4] 宋玉琴[1,2,3] 李忠武[1,2,5] 时云飞[1,2,5] 林宁晶[1,2,3] 王小沛[1,2,3] 涂梅峰[1,2,3] 应志涛[1,2,3] 平凌燕 刘卫平[1,2,3] 邓丽娟[1,2,3] 张晨[1,2,3] 朱军[1,2,3] 

机构地区：[1]北京大学临床肿瘤学院 [2]北京肿瘤医院 [3]北京市肿瘤防治研究所淋巴肿瘤科恶性肿瘤发病机制及转化研究教育部重点实验室,北京100142 [4]北京市肿瘤防治研究所肿瘤分子生物学实验室,北京100142 [5]北京市肿瘤防治研究所病理科,北京100142

出　　处：《现代生物医学进展》2011年第17期3275-3279,3289,共6页Progress in Modern Biomedicine

摘　　要：目的:探讨RIP3(受体相互作用蛋白-3)在淋巴瘤患者病理组织中是否表达及其亚细胞定位,并初步观察RIP3的表达是否与淋巴瘤病理恶性度相关。方法:(1)利用免疫组化技术检测48例淋巴瘤和非肿瘤侵润淋巴结病理组织中RIP3表达,并观察RIP3亚细胞定位。结果:(1)RIP3在淋巴瘤患者病理组织中均有表达,其亚细胞定位主要在细胞核,在细胞质中相对弱表达。(2)RIP3表达与淋巴瘤病理恶性度可能存在相关性。结论:RIP3在淋巴瘤患者病理组织中存在阳性表达,为研究RIP3是否与淋巴瘤的发病、临床表现和预后相关,提供了新的探索途径。Objective： To investigate the expression of RIP3 （receptor interaction protein-3） in lymphoma patients pathological tissues and the sub-cellular localization, and to investigate the relationship of the expression of RIP3 and malignant degree of lymphoma. Methods： The RIP3 expression in 48 cases of the lymphoma and non-neoplastic lymph node pathological tissues was detected by immunohistochemmistry, and the sub-cellular localization of RIP3 was observed. Results： 1） There were RIP3 expresses in the lymphoma pathological tissues, which mainly located in nucleus but weekly in cytoplasm. 2） The expression of RIP3 had a relationship with malignant degrees of lymphoma. Conclusion： There was RIP3 expression in lymphoma pathological tissues, which shell new light to the study of mechanism of lymphoma.

关 键 词：RIP3 淋巴瘤 病理 免疫组化 

分 类 号：R730.231[医药卫生—肿瘤]