射频热疗联合静脉加胸腔灌注化疗治疗恶性胸腔积液的疗效分析  

Treatment of malignant pleural effusion with radiofrequency hyperthermia combined with intravenous chemotherapy and intrapleural injection

作　　者：肖奇[1] 熊斌[1] 谢明水[1] 王晶[1] 付伟[1] 刘华平[1] 

机构地区：[1]中国人民解放军第92医院肿瘤科,南平353000

出　　处：《福建医药杂志》2011年第4期23-25,共3页Fujian Medical Journal

基　　金：福建省南平市科学技术研究基金项目(N2006Z19-13)

摘　　要：目的观察全身静脉加胸腔灌注化疗联合与不联合射频热疗治疗恶性胸腔积液的近期疗效及患者的生存质量变化情况。方法将89例确诊为非小细胞肺癌伴恶性胸腔积液的患者随机分为热化疗组46例和单纯化疗组43例。采用中心静脉导管胸腔闭式引流,尽可能排尽胸水后,热化疗组给予静脉化疗和胸腔灌注化疗,然后进行胸部射频热疗;单纯化疗组只给静脉化疗和胸腔灌注化疗。观察近期疗效和患者的生存质量。结果在控制恶性胸腔积液和改善生存质量方面热化疗组(82.61%,52.17%)均优于单纯化疗组(55.81%,30.23%),差异有统计学意义(均P<0.05)。结论射频热疗联合静脉化疗和胸腔灌注局部化疗对晚期肺癌合并恶性胸腔积液的治疗效果优于单纯静脉化疗联合胸腔灌注化疗,生活质量明显提高。Objective To observe the efficacy of treatment of malignant pleural effusion with radiofrequency hyperthermia combined with intravenous chemotherapy and intrapleural injection as well as survival quality.Methods Eighty-nine patients of non-small cell lung cancer（NSCLC） with malignant pleural effusion were randomly divided in to two groups.The treatment group（46 cases）were treated with intravenous chemotherapy and intrapleural injection combined with radiofrequency hyperthermia.The control group（43 cases）were treated with intravenous chemotherapy and intrapleural injection only.After treatment the curative and quality of life were evaluated.Results The treatment group（82.61%,52.17%） were more effective than the control group（55.81%,30.23%）in controlling the malignant pleural effusion and improving the quality of life.There was a significant difference between groups（P0.05）.Conclusion There should be a better clinical efficacy and physical condition for intravenous chemotherapy and intrapleural injection combined with radiofrequency hyperthermia than intravenous chemotherapy and intrapleural injection.

关 键 词：非小细胞肺癌 恶性胸腔积液 热疗 化学疗法 

分 类 号：R734.2[医药卫生—肿瘤] R730.58[医药卫生—临床医学]