大肠肿瘤p63、p73蛋白表达及相互关系的研究  

Expression and correlation of p63 and p73 protein in colorectal tumors

作　　者：郑晓玲[1,2] 何利平[1,2] 

机构地区：[1]福建医科大学省立临床医学院 [2]福建省立医院消化内镜中心,福州350001

出　　处：《福建医药杂志》2011年第4期81-83,共3页Fujian Medical Journal

基　　金：福建省卫生厅青年科研课题(2008-2-5)

摘　　要：目的探讨中国福建地区大肠肿瘤p63、p73表达与肿瘤细胞分化、浸润、淋巴结转移、解剖学位置的关系及二者表达的关联性。方法应用免疫组化技术检测p63、p73在50例大肠腺瘤、50例大肠癌及50例癌旁正常组织中的表达,结合大肠癌病理资料进行统计学分析。结果 p63、p73在大肠癌表达阳性率分别为34%、46%,明显高于大肠腺瘤和癌旁正常组织(均P<0.01),且阳性表达率与大肠癌细胞分化程度有明显关系(P<0.01),但与黏膜浸润深度、淋巴结转移、部位分布无明显关系(P>0.05)。两者在大肠癌中的表达有明显关系(P<0.01)。结论 p63、p73蛋白在大肠癌有一定的阳性表达率,该表达与大肠癌细胞分化程度相关,可能参与了大肠癌的恶性进展。Objective To study the expression of p63 and p73 protein in colorectal tumors in Fujian,China,and the relation of p63 and p73 expression in the cytodifferentiation,depth of invasion,lymph node metastases,anatomical position.Methods Immunohistochemical method was used to detect the expression of p63 and p73 protein in 50 cases of colorectal adenoma,50 cases of colorectal cancer,and 50 cases of colorectal normal mucosa.A statistical analysis was made according to clinicopathological data of colorectal cancer.Results The positive rate of expression of p63 and p73 protein in colorectal carcinoma was 34% and 46%,markedly higher than that in colorectal adenoma and normal mucosa.The difference was significant（P0.01）.The expression rate of p63 and p73 protein positively related with the cytodifferentiation（P0.01）,but there was not relevance of p63 and p73 protein with depth of invasion,lymph node metastases,and anatomical position（P0.05）.The correlativity was present between p63 and p73 protein expression（P0.01）.Conclusion p63 and p73 protein express partly in colorectal cancer,and the expression rate of p63 and p73 protein positively related with the cytodifferentiation.It suggests that p63 and p73 protein still have relativity with colorectal malignancy.

关 键 词：大肠癌 P63 P73 免疫组化 

分 类 号：R735.34[医药卫生—肿瘤]