AD患者血浆Leptin和血清Hcy、S100B、NSE联合检测的临床意义  

Clinical Significance of Determination of Plasma Leptin and Serum Hcy,S100B and NSE Levels in Patients with Alzheimer Disease

作　　者：窦焕芝 卢萌[1] 

机构地区：[1]镇江市第一人民医院核医学科,江苏镇江212000

出　　处：《标记免疫分析与临床》2011年第4期253-255,共3页Labeled Immunoassays and Clinical Medicine

摘　　要：探讨阿尔茨海默病(AD)患者血浆Leptin和血清Hcy、S100B、NSE水平的变化及临床意义。应用RIA和CLIA法测定32例AD患者血浆Leptin和血清Hcy、S100B、NSE水平,并与30名正常组作比较。结果表明AD患者血浆Leptin和血清Hcy、S100B、NSE水平与正常组比较,均有非常显著地升高(P<0.01),且Leptin水平与Hcy、S100B、NSE水平呈相关(r=0.5982、0.4762、0.6014,P<0.01)。检测AD患者血浆Leptin和血清Hcy、S100B、NSE水平对判断病情和评价疗效,均具有一定的临床价值。To explore the clinical significance of changes of plasma leptin and serun Hcy,S100B and NSE levels in patients with Alzheimer Disease（AD）.The plasma leptin and serum NSE levels in 32 AD patients and 30 controls were determined by using RIA,and the serum Hcy and S100B levels were measured by using CLIA.The results showed that the plasma leptin and serun Hcy,S100B and NSE levels in AD patients were significantly higher than these in controls（P0.01）.The plasma leptin levels in AD patients was mutually positively correlated with serum Hcy,S100B and NSE levels（r=0.5982,0.4762,0.6014,P0.01）.The detection of plasma leptin and serum Hcy,S100B and NSE levels may be helpful for the prediction of treatment efficiency in patients with Alzheimer disease.

关 键 词：阿尔茨海默病 瘦素 同型半胱氨酸 脑特异性蛋白100B 神经元特异性烯醇化酶 

分 类 号：R749.16[医药卫生—神经病学与精神病学]