IL-6、IL-23、CEA和CA19-9在结直肠癌患者的血清学表达及意义  

The Expression and Significance of Serum IL-6,IL-23,CEA and CA19-9 in Patients with Colorectal Cancer

作　　者：钟善传[1] 王丽[1] 董凤珍[1] 刘涤瑕[1] 唐德羽[1] 徐立风[1] 陈金超[1] 

机构地区：[1]中国人民解放军第532医院,245041

出　　处：《放射免疫学杂志》2011年第4期444-447,共4页Journal of Radioimmanology

摘　　要：目的:探讨单独或联检血清IL-6、IL-23、CEA和CA19-9在结直肠癌诊断中的价值,分析它们与结直肠癌临床分期的关系。方法:分别检测75例结直肠癌患者、60例结直肠良性病变患者和58例健康者IL-6、IL-23、CEA和CA19-9血清水平,分析它们对结直肠癌诊断的临床价值及其与临床病理因素之间的关系。结果:结直肠癌组四项指标血清水平均高于良性病变组和对照组。IL-6的ROC曲线下面积为0.892,IL-23为0.845,CEA为0.827,CA19-9为0.755;平行法联检可使诊断的灵敏性提高至94.7%,系列法联检则使特异性提高至95.0%。IL-6与肿瘤的浸润程度、淋巴结转移以及远处转移相关,IL-23和CEA与肿瘤的远处转移相关。结论:四项标志物血清水平对结直肠癌的诊断具有重要意义,联检可提高诊断灵敏性和特异性;IL-6、IL-23和CEA对结直肠癌的临床分期具有一定的作用。Objective To explore the value of single or combined detection of serum IL-6,IL-23,CEA and CA19-9 in the diagnosis of colorectal cancer and analyze the relationship between these markers and the clinical stage of colorectal cancer.Methods The levels of IL-6,IL-23,CEA and CA19-9 in the serum of human colorectal cancer group（75 cases）,colorectal benign lesion patients（60 cases） and healthy controls（58 cases） were determined,and their diagnostic value and relationship with clinical pathological parameters of patients with colorectal cancer was analyzed.Results In colorectal cancer patients,the serum concentrations of all the proteins tested were significantly higher than those in benign lesion patients and healthy controls.The areas under the receiver operating characteristic（ROC） curve of IL-6,IL-23,CEA and CA19-9 were 0.892,0.845,0.827 and 0.755,respectively.Method of parallel combined testing could increase the diagnostic sensitivity to 94.7%,and serial combined examination could increase the diagnostic specificity to 95.2%.Serum level of IL-6 was correlated with tumor TNM staging,IL-23 and CEA were correlated with distant metastasis.Conclusion Serum IL-6,IL-23,CEA and CA19-9 were useful markers for the diagnosis of patients with colorectal cancer,also combined detection of these markers could increase the sensitivity and specificity.IL-6,IL-23 and CEA were considerable factors for clinical staging of colorectal cancer.

关 键 词：结直肠癌 白细胞介素-6 白细胞介素-23 癌胚抗原 糖链抗原19-9 

分 类 号：R737.31[医药卫生—肿瘤]