cAMP/PKA/CREB信号通路及相关调控蛋白PDE-4和ERK对学习记忆的影响  

Influence of Learning and Memory on the Expression of Relevant Controlling Protein PDE-4 and Extracellular Signal Regulating Kinase

作　　者：杨夏[1] 彭生[2] 刘功俭[1] 

机构地区：[1]徐州医学院,江苏徐州221002 [2]苏州大学附属第四医院麻醉科,江苏无锡214000

出　　处：《医学综述》2011年第15期2241-2243,共3页Medical Recapitulate

基　　金：国家自然科学基金(81000469)

摘　　要：近年来在动物身上进行了大量的学习记忆实验,均提示cAMP/PKA/CREB信号通路中的各蛋白均与学习记忆过程有关。环磷酸腺苷(cAMP)激活蛋白激酶A磷酸化并激活cAMP反应单元结合蛋白(CREB),后者是一种重要的核蛋白,其调节启动子中具有cAMP反应单元(CRE)的基因转录,这种核转录因子具有调节包括学习记忆在内的广泛的生物学功能。已有研究证实,PDE4和ERK为cAMP/PKA/CREB信号通路的调节蛋白。现对cAMP/PKA/CREB信号通路中的各蛋白及其调控蛋白PDE-4和ERK进行研究,阐述着三者之间的关系,并探讨其对学习记忆的影响。In recent years,a lot of learning and memory tests which have been done with animals are all prompted that cAMP / PKA / CREB signaling pathway and the proteins are related to the process of learning and memory.PKA phosphorylates and activates cAMP response element binding protein（CREB）.The latter is an important nucleoprotein,and it regulates the gene transcription of a promoter that has cAMP.It has been confirmed that PDE-4 and ERK are cAMP /PKA/CREB signaling pathway regulatory protein.The cAMP/PKA/CREB signaling pathway and its regulated protein：PDE-4 and ERK,and the relationship among them,and explore its impact on learning and memory were reviewed in this article.

关 键 词：环磷酸腺苷 环磷酸腺苷反应元件结合蛋白 磷酸二酯酶4 细胞外信号调节激酶 学习记忆 

分 类 号：R614[医药卫生—麻醉学]